Interleukin 23
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit. IL-23 is part of the IL-12 family of cytokines. The functional receptor for IL-23 (the IL-23 receptor) consists of a heterodimer between IL-12Rβ1 and IL-23R.
| IL12B | |||||||
|---|---|---|---|---|---|---|---|
Crystal structure of IL-12B | |||||||
| Identifiers | |||||||
| Symbol | IL12B | ||||||
| Alt. symbols | CLMF2, NKSF2, p40 | ||||||
| NCBI gene | 3593 | ||||||
| HGNC | 5970 | ||||||
| OMIM | 161561 | ||||||
| PDB | 1F42 | ||||||
| RefSeq | NM_002187 | ||||||
| UniProt | P29460 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q31.1-33.1 | ||||||
| |||||||
| interleukin 23, alpha subunit p19 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL23A | ||||||
| NCBI gene | 51561 | ||||||
| HGNC | 15488 | ||||||
| RefSeq | NM_016584 | ||||||
| UniProt | Q9NPF7 | ||||||
| Other data | |||||||
| Locus | Chr. 12 q13.13 | ||||||
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