Interleukin-23 receptor

IL23R
Identifiers
Aliases	IL23R, interleukin 23 receptor
External IDs	OMIM: 607562 MGI: 2181693 HomoloGene: 16930 GeneCards: IL23R
Gene location (Human)
Chr.	Chromosome 1 (human)
End	67,259,979 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	67,468,839 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; amniotic fluid; ; rectum; ; islet of Langerhans; ; appendix; ; gallbladder; ; right adrenal gland; ; left adrenal gland; ; lymph node; ; pharynx;
	Top expressed in
	secondary oocyte; ; adrenal gland; ; thymus; ; ileum; ; jejunum; ; esophagus; ; uterus; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	interleukin-23 receptor activity; interleukin-12 receptor binding; protein binding; interleukin-23 binding; cytokine receptor activity; cytokine binding;
Cellular component	integral component of membrane; interleukin-23 receptor complex; membrane; receptor complex; plasma membrane; external side of plasma membrane;
Biological process	negative regulation of interleukin-10 production; response to interferon-gamma; positive regulation of interleukin-12 production; immune system process; positive regulation of T cell mediated cytotoxicity; positive regulation of interferon-gamma production; positive regulation of osteoclast differentiation; positive regulation of T-helper 17 cell lineage commitment; positive regulation of NK T cell activation; positive regulation of natural killer cell proliferation; response to lipopolysaccharide; positive regulation of T-helper 17 type immune response; positive regulation of T-helper 1 type immune response; positive regulation of granulocyte macrophage colony-stimulating factor production; defense response to Gram-negative bacterium; positive regulation of T cell proliferation; positive regulation of memory T cell differentiation; positive regulation of interleukin-17 production; innate immune response; inflammatory response; positive regulation of activated T cell proliferation; positive regulation of defense response to virus by host; positive regulation of activation of Janus kinase activity; regulation of tyrosine phosphorylation of STAT protein; positive regulation of tyrosine phosphorylation of STAT protein; cytokine-mediated signaling pathway; interleukin-23-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	149233
	209590
	ENSG00000162594
	ENSMUSG00000049093
	Q5VWK5
	Q8K4B4
	NM_144701
	NM_144548
	NP_653302
	NP_653131
	Wikidata
View/Edit Human	View/Edit Mouse

The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the IL23R gene. In complex with the interleukin-12 receptor β1 subunit (IL-12Rβ1), it is activated by the cytokine interleukin 23 (IL-23). The IL23R mRNA is 2.8 kilobases in length and includes 12 exons. The translated protein contains 629 amino acids; it is a type I penetrating protein and includes a signal peptide, an N-terminal fibronectin III-like domain and an intracellular part that contains three potential tyrosine phosphorylation domains. There are 24 IL23R splice variants in mitogen-activated lymphocytes. IL23R includes some single-nucleotide polymorphisms in the region encoding the domain that binds IL-23, which may lead to differences between people in Th17 activation. There is also a variant of IL-23R that consists of just the extracellular part and is known as soluble IL-23R. This form can compete with the membrane-bound form to bind IL-23, modulating the Th17 immune response and regulation of inflammation and immune function.

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