Interleukin 12
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35. Despite sharing many structural features and molecular partners, they mediate surprisingly diverse functional effects.
| Human Interleukin 12 | |
|---|---|
Crystal structure of human IL-12 (red helices) | |
| Identifiers | |
| Symbol | IL12, p70 |
| PDB | 1F45 |
| IL12A | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL12A | ||||||
| Alt. symbols | CLMF1, NKSF1, p35 | ||||||
| NCBI gene | 3592 | ||||||
| HGNC | 5969 | ||||||
| OMIM | 161560 | ||||||
| RefSeq | NM_000882 | ||||||
| UniProt | P29459 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p12-q13.2 | ||||||
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| interleukin 12B | |||||||
|---|---|---|---|---|---|---|---|
Crystal structure of IL-12B | |||||||
| Identifiers | |||||||
| Symbol | IL12B | ||||||
| Alt. symbols | CLMF2, NKSF2, p40 | ||||||
| NCBI gene | 3593 | ||||||
| HGNC | 5970 | ||||||
| OMIM | 161561 | ||||||
| PDB | 1F42 | ||||||
| RefSeq | NM_002187 | ||||||
| UniProt | P29460 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q31.1-33.1 | ||||||
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