Interleukin-12 subunit beta

IL12B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F42, 1F45, 3D85, 3D87, 3DUH, 3HMX, 3QWR, 4GRW, 4OE8, 4OG9
Identifiers
Aliases	IL12B, CLMF, CLMF2, IL-12B, IMD28, NKSF, NKSF2, IMD29, Interleukin 12 subunit beta, interleukin 12B
External IDs	OMIM: 161561 MGI: 96540 HomoloGene: 1648 GeneCards: IL12B
Gene location (Human)
Chr.	Chromosome 5 (human)
End	159,330,863 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	44,304,860 bp
RNA expression pattern
	Top expressed in
	lymph node; ; pituitary gland; ; appendix; ; tibialis anterior muscle; ; anterior pituitary; ; rectum; ; gallbladder; ; kidney; ; renal cortex; ; lower respiratory tract;
	Top expressed in
	thymus; ; tracheobronchial tree; ; spleen; ; trachea; ; carotid body; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; interleukin-23 receptor binding; protein homodimerization activity; interleukin-12 receptor binding; protein binding; identical protein binding; protein heterodimerization activity; interleukin-12 alpha subunit binding; cytokine receptor activity; growth factor activity; cytokine receptor binding; cytokine binding;
Cellular component	cytoplasm; membrane; interleukin-12 complex; interleukin-23 complex; extracellular region; extracellular space; endoplasmic reticulum lumen; cytosol; late endosome lumen; cell surface; external side of plasma membrane; receptor complex;
Biological process	positive regulation of cell adhesion; negative regulation of interleukin-10 production; negative regulation of smooth muscle cell proliferation; positive regulation of inflammatory response; sexual reproduction; positive regulation of interleukin-12 production; positive regulation of smooth muscle cell apoptotic process; defense response to Gram-negative bacterium; positive regulation of interleukin-10 production; positive regulation of T cell mediated cytotoxicity; natural killer cell activation; positive regulation of natural killer cell activation; positive regulation of interferon-gamma production; positive regulation of osteoclast differentiation; positive regulation of T-helper 17 cell lineage commitment; response to organic substance; positive regulation of NK T cell activation; positive regulation of natural killer cell proliferation; natural killer cell activation involved in immune response; cell surface receptor signaling pathway; positive regulation of NK T cell proliferation; positive regulation of T-helper 17 type immune response; negative regulation of inflammatory response to antigenic stimulus; defense response to virus; positive regulation of tissue remodeling; positive regulation of T-helper 1 type immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of T cell proliferation; positive regulation of memory T cell differentiation; cellular response to interferon-gamma; positive regulation of tumor necrosis factor production; T-helper 1 type immune response; sensory perception of pain; response to UV-B; positive regulation of interleukin-17 production; cellular response to lipopolysaccharide; negative regulation of interleukin-17 production; T-helper cell differentiation; cell migration; positive regulation of lymphocyte proliferation; positive regulation of mononuclear cell proliferation; positive regulation of activated T cell proliferation; defense response to protozoan; positive regulation of defense response to virus by host; positive regulation of activation of Janus kinase activity; regulation of tyrosine phosphorylation of STAT protein; positive regulation of tyrosine phosphorylation of STAT protein; interleukin-12-mediated signaling pathway; cell population proliferation; regulation of signaling receptor activity; T-helper 1 cell cytokine production; cytokine-mediated signaling pathway; interleukin-23-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	3593
	16160
	ENSG00000113302
	ENSMUSG00000004296
	P29460
	P43432
	NM_002187
	NM_008352; NM_001303244
	NP_002178
	NP_001290173
	Wikidata
View/Edit Human	View/Edit Mouse

Subunit beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12 subunit p40) is a protein subunit that in humans is encoded by the IL12B gene. IL-12B is a common subunit of interleukin 12 and interleukin 23.

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