Chromosome 5
Chromosome 5 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 5 spans about 182 million base pairs (the building blocks of DNA) and represents almost 6% of the total DNA in cells. Chromosome 5 is the 5th largest human chromosome, yet has one of the lowest gene densities. This is partially explained by numerous gene-poor regions that display a remarkable degree of non-coding and syntenic conservation with non-mammalian vertebrates, suggesting they are functionally constrained.
| Chromosome 5 | |
|---|---|
Human chromosome 5 pair after G-banding. One is from mother, one is from father. | |
Chromosome 5 pair in human male karyogram. | |
| Features | |
| Length (bp) | 182,045,439 bp (CHM13) |
| No. of genes | 839 (CCDS) |
| Type | Autosome |
| Centromere position | Submetacentric (48.8 Mbp) |
| Complete gene lists | |
| CCDS | Gene list |
| HGNC | Gene list |
| UniProt | Gene list |
| NCBI | Gene list |
| External map viewers | |
| Ensembl | Chromosome 5 |
| Entrez | Chromosome 5 |
| NCBI | Chromosome 5 |
| UCSC | Chromosome 5 |
| Full DNA sequences | |
| RefSeq | NC_000005 (FASTA) |
| GenBank | CM000667 (FASTA) |
Because chromosome 5 is responsible for many forms of growth and development (cell divisions) changes may cause cancers. One example would be acute myeloid leukemia (AML).
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.