IL12A

IL12A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F45, 3HMX
Identifiers
Aliases	IL12A, CLMF, IL-12A, NFSK, NKSF1, P35, interleukin 12A
External IDs	OMIM: 161560 MGI: 96539 HomoloGene: 681 GeneCards: IL12A
Gene location (Human)
Chr.	Chromosome 3 (human)
End	159,996,019 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	68,605,880 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; upper lobe of left lung; ; spleen; ; stromal cell of endometrium; ; amygdala; ; bronchial epithelial cell; ; cingulate gyrus; ; lymph node; ; monocyte; ; bone marrow cells;
	Top expressed in
	knee joint; ; triceps brachii muscle; ; quadriceps femoris muscle; ; skeletal muscle tissue; ; gastrocnemius muscle; ; spleen; ; temporal muscle; ; esophagus; ; blood; ; vastus lateralis muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; interleukin-27 binding; interleukin-12 beta subunit binding; protein binding; protein heterodimerization activity; growth factor activity; interleukin-12 receptor binding;
Cellular component	cytoplasm; interleukin-12 complex; extracellular region; extracellular space; endoplasmic reticulum lumen; late endosome lumen; cell surface;
Biological process	positive regulation of T cell differentiation; negative regulation of smooth muscle cell proliferation; extrinsic apoptotic signaling pathway; positive regulation of smooth muscle cell apoptotic process; response to virus; positive regulation of T cell mediated cytotoxicity; positive regulation of interferon-gamma production; positive regulation of natural killer cell activation; positive regulation of NK T cell activation; response to lipopolysaccharide; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; immune response; response to UV-B; cellular response to lipopolysaccharide; negative regulation of interleukin-17 production; cell migration; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of lymphocyte proliferation; positive regulation of dendritic cell chemotaxis; positive regulation of mononuclear cell proliferation; positive regulation of cell adhesion; defense response to protozoan; defense response to Gram-positive bacterium; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; interleukin-12-mediated signaling pathway; cell population proliferation; regulation of signaling receptor activity; T-helper 1 cell cytokine production; cytokine-mediated signaling pathway; interleukin-35-mediated signaling pathway; T-helper 1 cell activation;
	Sources:Amigo / QuickGO
Orthologs
	3592
	16159
	ENSG00000168811
	ENSMUSG00000027776
	P29459
	P43431
	NM_000882; NM_001354582; NM_001354583; NM_001397992
	NM_001159424; NM_008351
	NP_000873; NP_001341511; NP_001341512
	NP_001152896; NP_032377
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-12 subunit alpha (IL-12 p35) is a protein that in humans is encoded by the IL12A gene.

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