Interleukin 23 subunit alpha

IL23A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D85, 3D87, 3DUH, 3QWR, 4GRW, 4OE8, 4OG9
Identifiers
Aliases	IL23A, IL-23, IL-23A, IL23P19, P19, SGRF, Interleukin 23, interleukin 23 subunit alpha
External IDs	OMIM: 605580 MGI: 1932410 HomoloGene: 12832 GeneCards: IL23A
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,340,410 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,134,621 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; sperm; ; oocyte; ; oral cavity; ; amniotic fluid; ; monocyte; ; blood; ; secondary oocyte; ; right lobe of liver; ; islet of Langerhans;
	Top expressed in
	secondary oocyte; ; morula; ; atrioventricular valve; ; optic nerve; ; cumulus cell; ; endocardial cushion; ; ventricle; ; thymus; ; cerebellum; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; interleukin-23 receptor binding; protein binding;
Cellular component	interleukin-23 complex; extracellular region; extracellular space; endoplasmic reticulum lumen;
Biological process	negative regulation of interleukin-10 production; positive regulation of inflammatory response; positive regulation of interleukin-12 production; positive regulation of interleukin-10 production; immune system process; positive regulation of T cell mediated cytotoxicity; positive regulation of interferon-gamma production; positive regulation of natural killer cell activation; positive regulation of osteoclast differentiation; positive regulation of T-helper 17 cell lineage commitment; positive regulation of NK T cell activation; T cell proliferation; positive regulation of natural killer cell proliferation; positive regulation of NK T cell proliferation; positive regulation of T-helper 17 type immune response; defense response to virus; positive regulation of tissue remodeling; positive regulation of T-helper 1 type immune response; positive regulation of granulocyte macrophage colony-stimulating factor production; defense response to Gram-negative bacterium; positive regulation of T cell proliferation; immune response; positive regulation of memory T cell differentiation; positive regulation of neutrophil chemotaxis; positive regulation of tumor necrosis factor production; positive regulation of interleukin-17 production; innate immune response; inflammatory response; tissue remodeling; positive regulation of transcription by RNA polymerase II; positive regulation of activated T cell proliferation; positive regulation of defense response to virus by host; positive regulation of activation of Janus kinase activity; regulation of tyrosine phosphorylation of STAT protein; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; cytokine-mediated signaling pathway; interleukin-23-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	51561
	83430
	ENSG00000110944
	ENSMUSG00000025383
	Q9NPF7
	Q9EQ14
	NM_016584
	NM_031252
	NP_057668
	NP_112542
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. The protein is also known as IL-23p19. It is one of the two subunits of the cytokine Interleukin-23.

Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40 subunit. The IL-12p40, also known as Interleukin 12 subunit beta, is used by both IL-23 (where it partners with IL-23p19) and IL-12 (where it partners with IL-12A). A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of IL-12R β1 and IL-23R.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.