Calcitonin gene-related peptide

Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 (intermedin) and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produced by thyroid C cells whilst CGRP is secreted and stored in the nervous system. This peptide, in humans, exists in two forms: CGRP alpha (α-CGRP or CGRP I), and CGRP beta (β-CGRP or CGRP II). α-CGRP is a 37-amino acid neuropeptide and is formed by alternative splicing of the calcitonin/CGRP gene located on chromosome 11. β-CGRP is less studied. In humans, β-CGRP differs from α-CGRP by three amino acids and is encoded in a separate, nearby gene. The CGRP family includes calcitonin (CT), adrenomedullin (AM), and amylin (AMY).

Calcitonin-related polypeptide alpha
Human calcitonin (black) bound to the calcitonin receptor. PDB: 7TYO​
Identifiers
SymbolCALCA
Alt. symbolsCALC1
NCBI gene796
HGNC1437
OMIM114130
RefSeqNM_001741
UniProtP06881
Other data
LocusChr. 11 p15.2{{{LocusSupplementaryData}}}
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StructuresSwiss-model
DomainsInterPro
Calcitonin-related polypeptide, beta
Identifiers
SymbolCALCB
Alt. symbolsCALC2
NCBI gene797
HGNC1438
OMIM114160
RefSeqNM_000728
UniProtP10092
Other data
LocusChr. 11 p15.2{{{LocusSupplementaryData}}}
Search for
StructuresSwiss-model
DomainsInterPro
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