Calcitonin receptor

CALCR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5II0
Identifiers
Aliases	CALCR, CRT, CT-R, CTR, CTR1, calcitonin receptor
External IDs	OMIM: 114131 MGI: 101950 HomoloGene: 1320 GeneCards: CALCR
Gene location (Human)
Chr.	Chromosome 7 (human)
End	93,574,730 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	3,764,714 bp
RNA expression pattern
	Top expressed in
	tibia; ; hypothalamus; ; kidney; ; placenta; ; metanephros; ; skeletal muscle tissue; ; renal cortex; ; ligament; ; tendon; ; islet of Langerhans;
	Top expressed in
	arcuate nucleus; ; median eminence; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; suprachiasmatic nucleus; ; nucleus accumbens; ; lateral hypothalamus; ; ventromedial nucleus; ; morula; ; dorsal tegmental nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; calcitonin receptor activity; calcitonin binding; signal transducer activity; protein binding; transmembrane signaling receptor activity; amyloid-beta binding; calcitonin gene-related peptide receptor activity; amylin receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; axon; amylin receptor complex 1; amylin receptor complex 2; amylin receptor complex 3;
Biological process	positive regulation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; receptor internalization; response to glucocorticoid; activation of phospholipase C activity; activation of adenylate cyclase activity; cell surface receptor signaling pathway; protein transport; protein localization to plasma membrane; signal transduction; G protein-coupled receptor signaling pathway; positive regulation of gene expression; positive regulation of protein kinase A signaling; positive regulation of cell death; positive regulation of peptidyl-serine phosphorylation; cross-receptor inhibition within G protein-coupled receptor heterodimer; positive regulation of protein kinase B signaling; positive regulation of ERK1 and ERK2 cascade; amylin receptor signaling pathway; response to amyloid-beta; positive regulation of calcium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	799
	12311
	ENSG00000004948
	ENSMUSG00000023964
	P30988
	Q60755
	NM_001742; NM_001164737; NM_001164738
	NM_001042725; NM_007588; NM_001355192; NM_001377018
	NP_001158209; NP_001158210; NP_001733
	NP_001036190; NP_031614; NP_001342121; NP_001363947
	Wikidata
View/Edit Human	View/Edit Mouse

The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism.

CT works by activating the G-proteins G_s and G_q often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain. It may also affect the ovaries in women and the testes in men.

The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY₁ (CT + RAMP1), AMY₂ (CT + RAMP2), and AMY₃ (CT+ RAMP3).

Preclinical studies have suggested that dual amylin and calcitonin receptor agonists may be more effective than amylin receptor agonists for obesity and type II diabetes.

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