Calcitonin

CALCA
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2JXZ,%%s1LS7
Identifiers
Aliases	CALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
External IDs	OMIM: 114130 HomoloGene: 88401 GeneCards: CALCA
Gene location (Human)
Chr.	Chromosome 11 (human)
End	14,972,351 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; trigeminal ganglion; ; kidney; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; cerebellar vermis; ; islet of Langerhans; ; tibialis anterior muscle; ; right lobe of liver; ; left lobe of thyroid gland;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	hormone activity; calcitonin receptor binding; protein binding; identical protein binding; signaling receptor binding; protein-containing complex binding;
Cellular component	cytoplasm; intracellular anatomical structure; extracellular region; axon; terminal bouton; neuronal cell body; neuron projection; nucleus; extracellular space;
Biological process	cellular response to nerve growth factor stimulus; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; negative regulation of smooth muscle contraction; regulation of heart contraction; monocyte chemotaxis; negative regulation of blood pressure; positive regulation of cytosolic calcium ion concentration; cellular response to tumor necrosis factor; human ageing; vasodilation; cellular calcium ion homeostasis; response to heat; negative regulation of nervous system process; positive regulation of ossification; activation of adenylate cyclase activity; regulation of heart rate; detection of temperature stimulus involved in sensory perception of pain; negative regulation of ossification; response to pain; artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; feeding behavior; inflammatory response; neuropeptide signaling pathway; negative regulation of transcription, DNA-templated; activation of protein kinase activity; embryo implantation; negative regulation of bone resorption; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of cytosolic calcium ion concentration; leukocyte cell-cell adhesion; G protein-coupled receptor internalization; positive regulation of interleukin-1 alpha production; response to yeast; negative regulation of osteoclast differentiation; cell-cell signaling; antibacterial humoral response; positive regulation of macrophage differentiation; receptor internalization; regulation of blood pressure; protein phosphorylation; vasculature development; defense response to Gram-negative bacterium; endothelial cell proliferation; positive regulation of interleukin-8 production; nervous system process involved in regulation of systemic arterial blood pressure; negative regulation of calcium ion transport into cytosol; innate immune response; endothelial cell migration; antifungal humoral response; defense response to Gram-positive bacterium; antimicrobial humoral immune response mediated by antimicrobial peptide; amylin receptor signaling pathway; calcitonin gene-related peptide receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	796
	n/a
	ENSG00000110680
	n/a
	P06881
	n/a
	NM_001033952; NM_001033953; NM_001741; NM_001378949; NM_001378950
	n/a
	NP_001029125.1
	n/a
	Wikidata
View/Edit Human

Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates in the ultimopharyngeal body. It acts to reduce blood calcium (Ca²⁺), opposing the effects of parathyroid hormone (PTH).

Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis. It belongs to the calcitonin-like protein family.

Historically calcitonin has also been called thyrocalcitonin.

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