Adrenomedullin

ADM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FLY, 2L7S, 4RWF
Identifiers
Aliases	ADM, Adm, AM, PAMP, adrenomedullin
External IDs	OMIM: 103275 MGI: 108058 HomoloGene: 873 GeneCards: ADM
Gene location (Human)
Chr.	Chromosome 11 (human)
End	10,307,397 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	110,229,027 bp
RNA expression pattern
	Top expressed in
	vena cava; ; pericardium; ; saphenous vein; ; human penis; ; stromal cell of endometrium; ; synovial joint; ; glomerulus; ; metanephric glomerulus; ; subcutaneous adipose tissue; ; amniotic fluid;
	Top expressed in
	superior cervical ganglion; ; epithelium of stomach; ; atrium; ; renal corpuscle; ; stria vascularis; ; uterus; ; adrenal gland; ; left lung lobe; ; cervix; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; hormone activity; adrenomedullin receptor binding; protein binding;
Cellular component	extracellular region; cytoplasm; extracellular space;
Biological process	negative regulation of cell population proliferation; response to hypoxia; neural tube closure; branching involved in labyrinthine layer morphogenesis; antibacterial humoral response; defense response to Gram-negative bacterium; receptor internalization; blood circulation; signal transduction; animal organ regeneration; cell-cell signaling; response to lipopolysaccharide; vascular associated smooth muscle cell development; defense response to Gram-positive bacterium; positive regulation of cytosolic calcium ion concentration; vasculogenesis; negative regulation of vasoconstriction; G protein-coupled receptor internalization; cAMP-mediated signaling; calcium ion homeostasis; response to starvation; heart development; regulation of the force of heart contraction; positive regulation of apoptotic process; response to yeast; response to cold; positive regulation of vasculogenesis; neuron projection regeneration; hormone secretion; antifungal humoral response; positive regulation of cell population proliferation; response to glucocorticoid; developmental growth; human ageing; progesterone biosynthetic process; negative regulation of vascular permeability; androgen metabolic process; response to insulin; positive regulation of angiogenesis; response to organic substance; odontogenesis of dentin-containing tooth; spongiotrophoblast layer development; female pregnancy; response to wounding; cAMP biosynthetic process; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of systemic arterial blood pressure; positive regulation of heart rate; regulation of urine volume; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of signaling receptor activity; amylin receptor signaling pathway; adrenomedullin receptor signaling pathway; inflammatory response; positive regulation of progesterone biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	133
	11535
	ENSG00000148926
	ENSMUSG00000030790
	P35318
	P97297
	NM_001124
	NM_009627
	NP_001115
	NP_033757
	Wikidata
View/Edit Human	View/Edit Mouse

Adrenomedullin (ADM or AM) is a vasodilator peptide hormone of uncertain significance in human health and disease. It was initially isolated in 1993 from a pheochromocytoma, a tumor of the adrenal medulla: hence the name.

In humans ADM is encoded by the ADM gene. ADM is a peptide expressed by all tissues, and found in the circulation. A similar peptide named adreomedullin2 was reported in rats in 2004 which exhibits a similar function.

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