Karl Barry Sharpless

Karl Barry Sharpless
Karl Barry Sharpless
	Sharpless in 2018
Born	Karl Barry Sharpless; April 28, 1941; Philadelphia, Pennsylvania, U.S.
Alma mater	Dartmouth College (BA); Stanford University (MS, PhD)
Known for	Enantioselective synthesis; Click chemistry;
Spouse	Jan Dueser (m. 1965)
Awards	Chemical Pioneer Award (1988); Scheele Award (1991); Arthur C. Cope Award (1992); Tetrahedron Prize (1993); King Faisal International Prize (1995); Harvey Prize (1998); Chirality Medal (2000); Benjamin Franklin Medal (2001); Wolf Prize (2001); Nobel Prize in Chemistry (2001, 2022); William H. Nichols Medal (2006); Priestley Medal (2019);
	Scientific career
Fields	Stereochemistry
Institutions	Massachusetts Institute of Technology; Stanford University; The Scripps Research Institute; Kyushu University;
Thesis	Studies of the Mechanism of Action of 2,3-oxidosqualene-lanosterol cyclase: Featuring Enzymic Cyclization of Modified Squalene Oxides (1968)
Doctoral advisor	Eugene van Tamelen
Doctoral students	M.G. Finn
Other notable students	Undergrads: Gregory Fu; Post-docs: Eric Jacobsen; Hartmuth Kolb;

Karl Barry Sharpless (born April 28, 1941) is an American stereochemist. He is a two-time Nobel laureate in Chemistry known for his work on stereoselective reactions and click chemistry.

Sharpless was awarded half of the 2001 Nobel Prize in Chemistry "for his work on chirally catalysed oxidation reactions", and one third of the 2022 prize, jointly with Carolyn R. Bertozzi and Morten P. Meldal, "for the development of click chemistry and bioorthogonal chemistry". Sharpless is the fifth person (in addition to two organizations), to have twice been awarded a Nobel prize, along with Marie Curie, John Bardeen, Linus Pauling and Frederick Sanger, and the third to have been awarded two prizes in the same discipline (after Bardeen and Sanger).

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