Frederick Sanger

Frederick Sanger OM CH CBE FRS FAA (/ˈsæŋər/; 13 August 1918 – 19 November 2013) was a British biochemist who received the Nobel Prize in Chemistry twice.

Frederick Sanger

OM CH CBE FRS FAA
Born(1918-08-13)13 August 1918
Rendcomb, Gloucestershire, England
Died19 November 2013(2013-11-19) (aged 95)
Cambridge, England
Alma materSt John's College, Cambridge (BA, PhD)
Known for
  • Determining the amino acid sequence of insulin
  • Sanger sequencing
  • Sanger Centre
SpouseMargaret Joan Howe
Awards
Scientific career
FieldsBiochemistry
Institutions
  • University of Cambridge
  • Laboratory of Molecular Biology
ThesisThe metabolism of the amino acid lysine in the animal body (1943)
Doctoral advisorAlbert Neuberger
Doctoral students

He won the 1958 Chemistry Prize for determining the amino acid sequence of insulin and numerous other proteins, demonstrating in the process that each had a unique, definite structure; this was a foundational discovery for the central dogma of molecular biology.

At the newly constructed Laboratory of Molecular Biology in Cambridge, he developed and subsequently refined the first-ever DNA sequencing technique, which vastly expanded the number of feasible experiments in molecular biology and remains in widespread use today. The breakthrough earned him the 1980 Nobel Prize in Chemistry, which he shared with Walter Gilbert and Paul Berg.

He is one of only three people to have won multiple Nobel Prizes in the same category (the others being John Bardeen in physics and Karl Barry Sharpless in chemistry), and one of five persons with two Nobel Prizes.

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