Interleukin 20 receptor, alpha subunit

IL20RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DOH
Identifiers
Aliases	IL20RA, CRF2-8, IL-20R-alpha, IL-20R1, IL-20RA, Interleukin 20 receptor, alpha subunit, interleukin 20 receptor subunit alpha
External IDs	OMIM: 605620 MGI: 3605069 HomoloGene: 8685 GeneCards: IL20RA
Gene location (Human)
Chr.	Chromosome 6 (human)
End	137,045,180 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	19,635,801 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; right uterine tube; ; bronchial epithelial cell; ; endometrium; ; palpebral conjunctiva; ; minor salivary gland; ; body of pancreas; ; vagina; ; islet of Langerhans; ; parotid gland;
	Top expressed in
	spermatid; ; lip; ; superior frontal gyrus; ; skin of abdomen; ; adrenal gland; ; skin of back; ; carotid body; ; esophagus; ; olfactory bulb; ; epidermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; interleukin-20 binding; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	regulation of bone resorption; positive regulation of intrinsic apoptotic signaling pathway; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	53832
	237313
	ENSG00000016402
	ENSMUSG00000020007
	Q9UHF4
	Q6PHB0
	NM_001278722; NM_001278723; NM_001278724; NM_014432
	NM_172786
	NP_001265651; NP_001265652; NP_001265653; NP_055247
	NP_766374
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 20 receptor, alpha subunit, is a subunit of the interleukin-20 receptor, the interleukin-26 receptor, and the interleukin-24 receptor. The interleukin 20 receptor, alpha subunit is also referred to as IL20R1 or IL20RA. The IL20RA receptor is involved in both pro-inflammatory and anti-inflammatory responses, signaling through the JAK-STAT pathway.

IL20RA is found in the skin, lungs, ovaries, testes and placenta, with low gene expression in the intestine and liver. IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RA is also found in some immune cells.

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