Interleukin 24

IL24
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JVF, 6DF3, 6GG1
Identifiers
Aliases	IL24, C49A, FISP, IL10B, MDA7, MOB5, ST16, IL-24, interleukin 24
External IDs	OMIM: 604136 MGI: 2135548 HomoloGene: 4991 GeneCards: IL24
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,904,139 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	130,815,191 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; spleen; ; blood; ; lymph node; ; stromal cell of endometrium; ; appendix; ; mucosa of urinary bladder; ; gallbladder; ; gastrocnemius muscle; ; thymus;
	Top expressed in
	secondary oocyte; ; submandibular gland; ; placenta; ; uterus; ; integument; ; skin; ; zone of skin;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cytokine activity;
Cellular component	extracellular region; extracellular space;
Biological process	cellular response to interleukin-4; negative regulation of cell migration; wound healing; cellular response to lipopolysaccharide; positive regulation of cell population proliferation; negative regulation of cell population proliferation; apoptotic process; serine phosphorylation of STAT protein; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	11009
	93672
	ENSG00000162892
	ENSMUSG00000026420
	Q13007
	Q925S4
	NM_001185156; NM_001185157; NM_001185158; NM_006850; NM_181339
	NM_053095
	NP_001172085; NP_001172086; NP_001172087; NP_006841
	NP_444325
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 24 (IL-24) is a protein in the interleukin family, a type of cytokine signaling molecule in the immune system. In humans, this protein is encoded by the IL24 gene.

IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells and acts on skin, lung, and reproductive tissues. IL-24 performs important roles in wound healing, arthritis, psoriasis and cancer. Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24. The gene for IL-24 is located on chromosome 1 in humans.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.