Interleukin-20 receptor
Interleukin 20 receptors (IL20R) belong to the IL-10 family. IL20R are involved in both pro-inflammatory and anti-inflammatory immune response. There are two types of IL20R: Type I and Type II.
| interleukin 20 receptor, alpha | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL20RA | ||||||
| Alt. symbols | ZCYTOR7, IL-20R1 | ||||||
| NCBI gene | 53832 | ||||||
| HGNC | 6003 | ||||||
| OMIM | 605620 | ||||||
| RefSeq | NM_014432 | ||||||
| UniProt | Q9UHF4 | ||||||
| Other data | |||||||
| Locus | Chr. 6 q23.3 | ||||||
| |||||||
| interleukin 20 receptor beta | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL20RB | ||||||
| Alt. symbols | FNDC6 | ||||||
| NCBI gene | 53833 | ||||||
| HGNC | 6004 | ||||||
| OMIM | 605621 | ||||||
| RefSeq | NM_144717 | ||||||
| UniProt | Q6UXL0 | ||||||
| Other data | |||||||
| Locus | Chr. 3 q22.3 | ||||||
| |||||||
IL20R is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20R alpha and beta subunits have also been found in some immune cells. IL20R is implicated in diseases such as psoriasis, rheumatoid arthritis, and glaucoma.
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