Eslicarbazepine acetate

Eslicarbazepine acetate (ESL), sold under the brand names Aptiom and Zebinix among others, is an anticonvulsant medication approved for use in Europe and the United States as monotherapy or as additional therapy for partial-onset seizures epilepsy.

Eslicarbazepine acetate
Clinical data
Trade namesAptiom, Zebinix, Exalief
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding~30%
MetabolismUGT (?)
MetabolitesEslicarbazepine (active), glucuronides (inactive), etc.
Elimination half-life10–20 hours
Excretion~90% renal
Identifiers
  • (S)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.164.398
Chemical and physical data
FormulaC17H16N2O3
Molar mass296.326 g·mol−1
3D model (JSmol)
SMILES
  • CC(=O)O[C@H]1Cc2ccccc2N(C(N)=O)c2ccccc21
  • InChI=1S/C17H16N2O3/c1-11(20)22-16-10-12-6-2-4-8-14(12)19(17(18)21)15-9-5-3-7-13(15)16/h2-9,16H,10H2,1H3,(H2,18,21)/t16-/m0/s1
  • Key:QIALRBLEEWJACW-INIZCTEOSA-N

Similarly to oxcarbazepine, ESL behaves as a prodrug to (S)-(+)-licarbazepine. As such, their mechanisms of action are identical.

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