DPP8

DPP8
Identifiers
Aliases	DPP8, DP8, DPRP1, MSTP141, MST097, MSTP097, MSTP135, DPRP-1, dipeptidyl peptidase 8
External IDs	OMIM: 606819 MGI: 1921638 HomoloGene: 57098 GeneCards: DPP8
Gene location (Human)
Chr.	Chromosome 15 (human)
End	65,517,704 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	64,989,933 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; nipple; ; middle temporal gyrus; ; pons; ; postcentral gyrus; ; Brodmann area 23; ; biceps brachii; ; superior vestibular nucleus; ; palpebral conjunctiva; ; jejunum;
	Top expressed in
	spermatocyte; ; superior frontal gyrus; ; aortic valve; ; cerebellar cortex; ; ascending aorta; ; temporal muscle; ; inferior colliculus; ; entorhinal cortex; ; spermatid; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; aminopeptidase activity; dipeptidyl-peptidase activity; hydrolase activity;
Cellular component	cytoplasm; cytosol;
Biological process	immune response; proteolysis; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	54878
	74388
	ENSG00000074603
	ENSMUSG00000032393
	Q6V1X1
	Q80YA7
NM_017743; NM_130434; NM_197960; NM_197961; NM_001320875;
	NM_001320876
	NM_028906; NM_001401136
NP_001307804; NP_001307805; NP_060213; NP_569118; NP_932064;
	NP_932065; NP_932064.1; NP_001307804.1
	NP_083182; NP_001388065
	Wikidata
View/Edit Human	View/Edit Mouse

Dipeptidyl peptidase 8 is an enzyme that in humans is encoded by the DPP8 gene.

This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase-4 in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. A relatively specific inhibitor of DPP8 and DPP9, Val-boroPro -, leads to increased activation of the inflammasome though both NLRBP1 and CARD8 and can trigger pyroptosis.

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