DPP9

DPP9
Identifiers
Aliases	DPP9, DP9, DPLP9, DPRP-2, DPRP2, dipeptidyl peptidase 9, DPP IX
External IDs	OMIM: 608258 MGI: 2443967 HomoloGene: 16385 GeneCards: DPP9
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,724,673 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,525,905 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; right lobe of liver; ; pancreatic ductal cell; ; appendix; ; upper lobe of left lung; ; stromal cell of endometrium; ; sural nerve; ; bone marrow cells; ; skin of abdomen; ; spleen;
	Top expressed in
	interventricular septum; ; islet of Langerhans; ; internal carotid artery; ; lacrimal gland; ; knee joint; ; external carotid artery; ; skeletal muscle tissue; ; superior cervical ganglion; ; facial motor nucleus; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; aminopeptidase activity; hydrolase activity; identical protein binding;
Cellular component	nucleus; cytoplasm; cytosol;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	91039
	224897
	ENSG00000142002
	ENSMUSG00000001229
	Q86TI2
	Q8BVG4
	NM_139159; NM_001365987
	NM_172624; NM_001360284
	NP_631898; NP_001352916
	NP_766212; NP_001347213
	Wikidata
View/Edit Human	View/Edit Mouse

Dipeptidyl peptidase 9 is an enzyme that in humans is encoded by the DPP9 gene.

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound.

In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. More specifically, DPP9 interacts with the NLRP1 protein and affects the level of activation of the NLRP1 inflammasome. This function involves binding to a complex of full-length NLRP1 and a proinflammatory fragment of NLRP1 after activation by autocleavage. A similar mechanism allows DPP9 to regulate the CARD8 inflammasome.

This gene has also been linked to severe COVID-19.

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