Caspase recruitment domain-containing protein 8

CARD8
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4IKM
Identifiers
Aliases	CARD8, CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN, caspase recruitment domain family member 8
External IDs	OMIM: 609051 HomoloGene: 136365 GeneCards: CARD8
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,255,946 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spleen; ; blood; ; lymph node; ; gallbladder; ; appendix; ; Achilles tendon; ; right lung; ; bone marrow cells; ; upper lobe of left lung;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type endopeptidase activator activity involved in apoptotic process; protein binding; protein homodimerization activity; NACHT domain binding; CARD domain binding; identical protein binding;
Cellular component	NLRP3 inflammasome complex; nucleoplasm; cytoplasm; nucleus; cytosol; protein-containing complex; inflammasome complex;
Biological process	apoptotic process; regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of I-kappaB kinase/NF-kappaB signaling; activation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of tumor necrosis factor-mediated signaling pathway; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of NF-kappaB transcription factor activity; inhibition of cysteine-type endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	22900
	n/a
	ENSG00000105483
	n/a
	Q9Y2G2
	n/a
NM_001184900; NM_001184901; NM_001184902; NM_001184903; NM_001184904;
	NM_014959; NM_001351782; NM_001351783; NM_001351784; NM_001351786; NM_001351787; NM_001351788; NM_001351789; NM_001351790; NM_001351791; NM_001351792; NM_001365950
	n/a
NP_001171829; NP_001171830; NP_001171831; NP_001171832; NP_001171833;
	NP_055774; NP_001338711; NP_001338712; NP_001338713; NP_001338715; NP_001338716; NP_001338717; NP_001338718; NP_001338719; NP_001338720; NP_001338721; NP_001352879
	n/a
	Wikidata
View/Edit Human

Caspase recruitment domain-containing protein 8 is a protein that in humans is encoded by the CARD8 gene.

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