Cycle (gene)
Cycle (cyc) is a gene in Drosophila melanogaster that encodes the CYCLE protein (CYC). The Cycle gene (cyc) is expressed in a variety of cell types in a circadian manner. It is involved in controlling both the sleep-wake cycle and circadian regulation of gene expression by promoting transcription in a negative feedback mechanism. The cyc gene is located on the left arm of chromosome 3 and codes for a transcription factor containing a basic helix-loop-helix (bHLH) domain and a PAS domain. The 2.17 kb cyc gene is divided into 5 coding exons totaling 1,625 base pairs which code for 413 aminos acid residues. Currently 19 alleles are known for cyc . Orthologs performing the same function in other species include ARNTL and ARNTL2.
| Cycle | |||||||
|---|---|---|---|---|---|---|---|
The approximate 3D structure of CYC protein generated with Phyre2. The protein sequence information was obtained from the UniProt database. | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | cyc | ||||||
| Entrez | 40162 | ||||||
| RefSeq (mRNA) | NM_079444.3 | ||||||
| RefSeq (Prot) | NP_524168.2 | ||||||
| UniProt | O61734 | ||||||
| Other data | |||||||
| Chromosome | 3L: 19.81 - 19.81 Mb | ||||||
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| aryl hydrocarbon receptor nuclear translocator-like | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ARNTL | ||||||
| Alt. symbols | bmal1 | ||||||
| NCBI gene | 406 | ||||||
| HGNC | 701 | ||||||
| OMIM | 602550 | ||||||
| RefSeq | NP_001025443 | ||||||
| UniProt | O00327 | ||||||
| Other data | |||||||
| Locus | Chr. 11 p15 | ||||||
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