ARNTL2

ARNTL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KDK
Identifiers
Aliases	ARNTL2, BMAL2, CLIF, MOP9, PASD9, bHLHe6, aryl hydrocarbon receptor nuclear translocator like 2
External IDs	OMIM: 614517 MGI: 2684845 HomoloGene: 10609 GeneCards: ARNTL2
Gene location (Human)
Chr.	Chromosome 12 (human)
End	27,425,289 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	146,735,027 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; oral cavity; ; islet of Langerhans; ; gums; ; vagina; ; stromal cell of endometrium; ; cervix epithelium; ; thymus; ; middle temporal gyrus; ; body of tongue;
	Top expressed in
	secondary oocyte; ; esophagus; ; female urethra; ; superior frontal gyrus; ; lip; ; cumulus cell; ; lens; ; facial motor nucleus; ; stomach; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; E-box binding; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; nucleolus; nucleus; transcription regulator complex;
Biological process	regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of circadian rhythm; regulation of transcription, DNA-templated; circadian rhythm; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; rhythmic process; entrainment of circadian clock;
	Sources:Amigo / QuickGO
Orthologs
	56938
	272322
	ENSG00000029153
	ENSMUSG00000040187
	Q8WYA1
	Q2VPD4
NM_001248002; NM_001248003; NM_001248004; NM_001248005; NM_020183;
	NM_001394524; NM_001394525; NM_001394526; NM_001394527; NM_001394528; NM_001394529
	NM_172309; NM_001289679; NM_001289680; NM_001289681
	NP_001234931; NP_001234932; NP_001234933; NP_001234934; NP_064568
	NP_001276608; NP_001276609; NP_001276610; NP_758513
	Wikidata
View/Edit Human	View/Edit Mouse

Aryl hydrocarbon receptor nuclear translocator-like 2, also known as Arntl2, Mop9, Bmal2, or Clif, is a gene.

Arntl2 is a paralog to Arntl, which are both homologs of the Drosophila Cycle. Homologs were also isolated in fish, birds and mammals such as mice and humans. Based on phylogenetic analyses, it was proposed that Arntl2 arose from duplication of the Arntl gene early in the vertebrate lineage, followed by rapid divergence of the Arntl gene copy. The protein product of the gene interacts with both CLOCK and NPAS2 to bind to E-box sequences in regulated promoters and activate their transcription. Although Arntl2 is not required for normal function of the mammalian circadian oscillator, it may play an important role in mediating the output of the circadian clock. Perhaps because of this, there is relatively little published literature on the role of Arntl2 in regulation of physiology.

Arntl2 is a candidate gene for human type 1 diabetes.

In overexpression studies, ARNTL2 protein forms a heterodimer with CLOCK to regulate E-box sequences in the Pai-1 promoter. Recent work suggest that this interaction may be in concert with ARNTL/CLOCK heterodimeric complexes.

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