Basic helix-loop-helix ARNT-like protein 1

ARNTL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H10
Identifiers
Aliases	ARNTL, BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC, bHLHe5, aryl hydrocarbon receptor nuclear translocator like
External IDs	OMIM: 602550 MGI: 1096381 HomoloGene: 910 GeneCards: ARNTL
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	112,913,333 bp
RNA expression pattern
	n/a
	Top expressed in
	secondary oocyte; ; thymus; ; sternocleidomastoid muscle; ; suprachiasmatic nucleus; ; temporal muscle; ; triceps brachii muscle; ; digastric muscle; ; knee joint; ; barrel cortex; ; visual cortex;
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; Hsp90 protein binding; protein dimerization activity; DNA-binding transcription factor activity; aryl hydrocarbon receptor binding; protein binding; transcription cis-regulatory region binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; core promoter sequence-specific DNA binding; bHLH transcription factor binding; sequence-specific DNA binding; protein heterodimerization activity; E-box binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; PML body; intracellular membrane-bounded organelle; transcription regulator complex; nucleoplasm; nucleus; nuclear body; chromatoid body;
Biological process	regulation of transcription, DNA-templated; rhythmic process; transcription, DNA-templated; regulation of hair cycle; transcription by RNA polymerase II; spermatogenesis; circadian rhythm; negative regulation of TOR signaling; circadian regulation of gene expression; regulation of protein catabolic process; positive regulation of circadian rhythm; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of fat cell differentiation; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; regulation of neurogenesis; regulation of insulin secretion; regulation of cell cycle; response to redox state; maternal process involved in parturition; positive regulation of canonical Wnt signaling pathway; oxidative stress-induced premature senescence; regulation of type B pancreatic cell development; negative regulation of glucocorticoid receptor signaling pathway; regulation of cellular senescence; positive regulation of skeletal muscle cell differentiation; positive regulation of protein acetylation; negative regulation of cold-induced thermogenesis; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	406
	11865
	ENSG00000133794
	ENSMUSG00000055116
	O00327
	Q9WTL8
NM_001030272; NM_001030273; NM_001178; NM_001297719; NM_001297722;
	NM_001297724
	NM_001243048; NM_007489; NM_001357070; NM_001368412; NM_001374642
NP_001025443; NP_001025444; NP_001169; NP_001284648; NP_001284651;
	NP_001284653; NP_001338733; NP_001338734; NP_001338735; NP_001338736; NP_001338737; NP_001338738; NP_001338739; NP_001338740; NP_001338741; NP_001338742; NP_001338743; NP_001338744; NP_001338745; NP_001338746; NP_001338747; NP_001338748; NP_001338749; NP_001338750; NP_001338751; NP_001338752; NP_001338753
	NP_001229977; NP_031515; NP_001343999; NP_001355341; NP_001361571
	Wikidata
View/Edit Human	View/Edit Mouse

Basic helix-loop-helix ARNT-like protein 1 or aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL), or brain and muscle ARNT-like 1 is a protein that in humans is encoded by the BMAL1 gene on chromosome 11, region p15.3. It's also known as MOP3, and, less commonly, bHLHe5, BMAL, BMAL1C, JAP3, PASD3, and TIC.

BMAL1 encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human BMAL1 gene has a predicted 24 exons, located on the p15 band of the 11th chromosome. The BMAL1 protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian auto-regulatory transcription-translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. Research has revealed that BMAL1 is the only clock gene without which the circadian clock fails to function in humans. BMAL1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in BMAL1 have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns. BMAL1, according to genome-wide profiling, is estimated to target more than 150 sites in the human genome, including all of the clock genes and genes encoding for proteins that regulate metabolism.

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