CENPJ

CENPJ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5ITZ
Identifiers
Aliases	CENPJ, BM032, CENP-J, CPAP, LAP, LIP1, MCPH6, SASS4, SCKL4, Sas-4, centromere protein J
External IDs	OMIM: 609279 MGI: 2684927 HomoloGene: 10204 GeneCards: CENPJ
Gene location (Human)
Chr.	Chromosome 13 (human)
End	24,922,889 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	56,812,882 bp
RNA expression pattern
	Top expressed in
	sperm; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; ganglionic eminence; ; Brodmann area 23; ; spongy bone; ; rectum; ; right uterine tube; ; canal of the cervix; ; tibial nerve;
	Top expressed in
	secondary oocyte; ; hand; ; ganglionic eminence; ; primitive streak; ; thymus; ; testicle; ; seminiferous tubule; ; maxillary prominence; ; medial ganglionic eminence; ; medullary collecting duct;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein kinase binding; protein domain specific binding; tubulin binding; identical protein binding; transcription corepressor activity;
Cellular component	cytoplasm; microtubule organizing center; gamma-tubulin small complex; cytosol; centrosome; microtubule; cytoskeleton; centriole; nucleoplasm; plasma membrane; ciliary basal body; nucleus;
Biological process	regulation of centriole replication; centriole replication; microtubule polymerization; G2/M transition of mitotic cell cycle; microtubule nucleation; centriole elongation; cell division; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; smoothened signaling pathway; motile cilium assembly; centrosome duplication; centriole assembly; positive regulation of non-motile cilium assembly; non-motile cilium assembly; positive regulation of centriole elongation; positive regulation of establishment of protein localization; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	55835
	219103
	ENSG00000151849
	ENSMUSG00000064128
	Q9HC77
	Q569L8
	NM_018451
	NM_001014996
	NP_060921
	NP_001014996; NP_001390462; NP_001390463
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein J is a protein that in humans is encoded by the CENPJ gene. It is also known as centrosomal P4.1-associated protein (CPAP). During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein.

The Drosophila ortholog, sas-4, has been shown to be a scaffold for a cytoplasmic complex of Cnn, Asl, CP-190, tubulin and D-PLP (similar to the human proteins PCNT and AKAP9). These complexes are then anchored at the centriole to begin formation of the centrosome.

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