CREB-binding protein

CREBBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JSP, 1LIQ, 1RDT, 1WO3, 1WO4, 1WO5, 1WO6, 1WO7, 2D82, 2KJE, 2KWF, 2L84, 2L85, 2LXS, 2LXT, 2RNY, 3DWY, 3P1C, 3P1D, 3P1E, 3P1F, 3SVH, 4A9K, 4N3W, 4N4F, 4NR4, 4NR5, 4NR6, 4NR7, 4NYV, 4NYW, 4NYX, 4OUF, 4TQN, 4TS8, 4WHU, 5JEM, 5I8B, 5I89, 5I86, 4YK0, 5CGP, 5I8G, 2N1A, 5I83, 1ZOQ, 5DBM
Identifiers
Aliases	CREBBP, AW558298, CBP, CBP/p300, KAT3A, p300/CBP, RSTS, CREB binding protein, RSTS1, MKHK1
External IDs	OMIM: 600140 MGI: 1098280 HomoloGene: 68393 GeneCards: CREBBP
Gene location (Human)
Chr.	Chromosome 16 (human)
End	3,880,713 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	4,031,861 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; tibia; ; amniotic fluid; ; germinal epithelium; ; Achilles tendon; ; endothelial cell; ; bone marrow cells; ; caput epididymis; ; lactiferous duct; ; blood;
	Top expressed in
	ascending aorta; ; aortic valve; ; cumulus cell; ; secondary oocyte; ; ciliary body; ; blood; ; vas deferens; ; cingulate gyrus; ; fossa; ; primitive streak;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; transcription coactivator activity; MRF binding; zinc ion binding; p53 binding; transcription factor binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; transcription coregulator activity; signal transducer activity; metal ion binding; histone acetyltransferase activity; damaged DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; acetyltransferase activity; acyltransferase activity; peptide N-acetyltransferase activity; DNA-binding transcription factor activity; transcription corepressor activity;
Cellular component	cytoplasm; nucleoplasm; histone acetyltransferase complex; nucleus; nuclear body;
Biological process	Notch signaling pathway; response to hypoxia; regulation of transcription, DNA-templated; rhythmic process; cellular response to UV; embryonic digit morphogenesis; N-terminal peptidyl-lysine acetylation; stimulatory C-type lectin receptor signaling pathway; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; regulation of smoothened signaling pathway; histone acetylation; regulation of transcription from RNA polymerase II promoter in response to hypoxia; regulation of cellular response to heat; transcription initiation from RNA polymerase II promoter; viral process; positive regulation of type I interferon production; signal transduction; protein acetylation; homeostatic process; beta-catenin-TCF complex assembly; regulation of apoptotic process; positive regulation of transcription by RNA polymerase II; regulation of lipid metabolic process; protein destabilization; regulation of myeloid cell differentiation; positive regulation of transcription of Notch receptor target; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of Notch signaling pathway; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	1387
	12914
	ENSG00000005339
	ENSMUSG00000022521
	Q92793
	P45481
	NM_001079846; NM_004380
	NM_001025432
	NP_001073315; NP_004371
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

CREB-binding protein, also known as CREBBP or CBP or KAT3A, (where CREB is cAMP response element-binding protein) is a coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13.3. CBP has intrinsic acetyltransferase functions; it is able to add acetyl groups to both transcription factors as well as histone lysines, the latter of which has been shown to alter chromatin structure making genes more accessible for transcription. This relatively unique acetyltransferase activity is also seen in another transcription enzyme, EP300 (p300). Together, they are known as the p300-CBP coactivator family and are known to associate with more than 16,000 genes in humans; however, while these proteins share many structural features, emerging evidence suggests that these two co-activators may promote transcription of genes with different biological functions.

For example, CBP alone has been implicated in a wide variety of pathophysiologies including colorectal cancer as well as head and neck squamous cell carcinoma. In these diseases, association of CBP with β-catenin has been shown to promote cancer cell proliferation and disease aggressiveness, whereas p300/ β-catenin leads to cell differentiation and/ or apoptosis. CBP has also been shown to help modulate liver function via maintenance of energy homeostasis in response to changes in cell nutrition conditions by regulating the activity of transcription factors and genes responsible for lipogenesis and gluconeogenesis. CBP is also implicated in the etiologies of several other diseases including hematologic malignancies and other solid tumors, diabetes, schizophrenia, Alzheimer's disease, depression, and many other neurological conditions.

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