EP300

EP300
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT3
Identifiers
Aliases	EP300, KAT3B, RSTS2, p300, E1A binding protein p300, MKHK2
External IDs	OMIM: 602700 MGI: 1276116 HomoloGene: 1094 GeneCards: EP300
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,180,077 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,536,278 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; lower lobe of lung; ; thymus; ; visceral pleura; ; parietal pleura; ; corpus callosum; ; monocyte; ; sural nerve; ; Achilles tendon; ; testicle;
	Top expressed in
	hand; ; submandibular gland; ; spleen; ; secondary oocyte; ; blood; ; ciliary body; ; thymus; ; conjunctival fornix; ; suprachiasmatic nucleus; ; vas deferens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein C-terminus binding; transcription factor binding; transcription coregulator activity; metal ion binding; acyltransferase activity; transferase activity; beta-catenin binding; pre-mRNA intronic binding; zinc ion binding; chromatin binding; damaged DNA binding; protein binding; acetyltransferase activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription coactivator activity; p53 binding; androgen receptor binding; chromatin DNA binding; histone acetyltransferase activity; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; peptide N-acetyltransferase activity; peptide-lysine-N-acetyltransferase activity; protein propionyltransferase activity; STAT family protein binding; peptide butyryltransferase activity; histone crotonyltransferase activity; histone butyryltransferase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus; histone acetyltransferase complex; transcription regulator complex; nucleoplasm; cytoplasm; cytosol; chromosome;
Biological process	somitogenesis; rhythmic process; transcription by RNA polymerase II; histone H2B acetylation; animal organ morphogenesis; cell cycle; B cell differentiation; apoptotic process; regulation of transcription, DNA-templated; lung development; N-terminal peptidyl-lysine acetylation; platelet formation; stimulatory C-type lectin receptor signaling pathway; transcription, DNA-templated; positive regulation of transcription, DNA-templated; heart development; regulation of transcription from RNA polymerase II promoter in response to hypoxia; viral process; protein acetylation; Notch signaling pathway; cellular response to UV; protein stabilization; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; nervous system development; regulation of autophagy; regulation of androgen receptor signaling pathway; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; fat cell differentiation; positive regulation by host of viral transcription; megakaryocyte development; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; internal protein amino acid acetylation; regulation of cell cycle; regulation of tubulin deacetylation; positive regulation of gene expression; histone H4 acetylation; regulation of cellular response to heat; transcription-coupled nucleotide-excision repair; skeletal muscle tissue development; positive regulation of type I interferon production; response to estrogen; response to hypoxia; regulation of signal transduction by p53 class mediator; internal peptidyl-lysine acetylation; beta-catenin-TCF complex assembly; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; macrophage derived foam cell differentiation; circadian rhythm; protein deubiquitination; positive regulation of transcription by RNA polymerase II; protein destabilization; regulation of megakaryocyte differentiation; histone acetylation; epigenetic maintenance of chromatin in transcription-competent conformation; peptidyl-lysine propionylation; peptidyl-lysine crotonylation; peptidyl-lysine butyrylation;
	Sources:Amigo / QuickGO
Orthologs
	2033
	328572
	ENSG00000100393
	ENSMUSG00000055024
	Q09472
	B2RWS6
	NM_001429; NM_001362843
	NM_177821
	NP_001420; NP_001349772
	NP_808489
	Wikidata
View/Edit Human	View/Edit Mouse

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.

The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein.

EP300 is closely related to another gene, CREB binding protein, which is found on human chromosome 16.

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