C-C chemokine receptor type 7

CCR7
Identifiers
Aliases	CCR7, BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1, C-C motif chemokine receptor 7
External IDs	OMIM: 600242 MGI: 103011 HomoloGene: 1387 GeneCards: CCR7
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,565,472 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,045,903 bp
RNA expression pattern
	Top expressed in
	appendix; ; lymph node; ; blood; ; thymus; ; spleen; ; superficial temporal artery; ; bone marrow; ; thymus; ; nasopharynx; ; bone marrow cells;
	Top expressed in
	blood; ; spleen; ; thymus; ; subcutaneous adipose tissue; ; right lung lobe; ; bone marrow; ; white adipose tissue; ; mammary gland; ; left lung; ; meninges;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	C-C motif chemokine 19 receptor activity; C-C motif chemokine 21 receptor activity; G protein-coupled receptor activity; chemokine (C-C motif) ligand 19 binding; chemokine (C-C motif) ligand 21 binding; signal transducer activity; chemokine receptor activity; C-C chemokine receptor activity; chemokine binding; C-C chemokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; intracellular anatomical structure; cell surface; external side of plasma membrane; mitochondrion;
Biological process	G protein-coupled receptor signaling pathway; release of sequestered calcium ion into cytosol; positive regulation of protein kinase B signaling; positive regulation of cell motility; positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation; positive regulation of actin filament polymerization; lymphocyte migration into lymph node; homeostasis of number of cells; positive regulation of interleukin-12 production; positive regulation of hypersensitivity; activation of GTPase activity; ruffle organization; positive regulation of cell-matrix adhesion; positive regulation of cytosolic calcium ion concentration; positive regulation of T cell receptor signaling pathway; regulation of interferon-gamma production; response to nitric oxide; regulation of dendritic cell dendrite assembly; positive regulation of JNK cascade; myeloid dendritic cell chemotaxis; dendritic cell chemotaxis; cellular response to cytokine stimulus; negative thymic T cell selection; positive regulation of phosphatidylinositol 3-kinase activity; chemotaxis; positive regulation of immunological synapse formation; response to prostaglandin E; response to lipopolysaccharide; positive regulation of dendritic cell antigen processing and presentation; positive regulation of pseudopodium assembly; positive regulation of humoral immune response; immune response; establishment of T cell polarity; positive regulation of ERK1 and ERK2 cascade; positive regulation of neutrophil chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of T cell costimulation; inflammatory response; mature conventional dendritic cell differentiation; positive regulation of filopodium assembly; positive regulation of dendritic cell chemotaxis; signal transduction; positive regulation of cell adhesion; positive regulation of protein kinase activity; chemokine-mediated signaling pathway; chemokine (C-C motif) ligand 19 signaling pathway; chemokine (C-C motif) ligand 21 signaling pathway; negative regulation of dendritic cell apoptotic process; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	1236
	12775
	ENSG00000126353
	ENSMUSG00000037944
	P32248
	P47774
	NM_001838; NM_001301714; NM_001301716; NM_001301717; NM_001301718
	NM_001301713; NM_007719
	NP_001288643; NP_001288645; NP_001288646; NP_001288647; NP_001829
	NP_001288642; NP_031745
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19/ELC) and (C-C motif) ligand 21 (CCL21). The ligands have similar affinity for the receptor, though CCL19 has been shown to induce internalisation of CCR7 and desensitisation of the cell to CCL19/CCL21 signals. CCR7 is a transmembrane protein with 7 transmembrane domains, which is coupled with heterotrimeric G proteins, which transduce the signal downstream through various signalling cascades. The main function of the receptor is to guide immune cells to immune organs (lymph nodes, thymus, spleen) by detecting specific chemokines, which these tissues secrete.

CCR7 has also recently been designated CD197 (cluster of differentiation 197).

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