CCL21

CCL21
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L4N
Identifiers
Aliases	CCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 21
External IDs	OMIM: 602737 MGI: 1349183 HomoloGene: 2247 GeneCards: CCL21
Gene location (Human)
Chr.	Chromosome 9 (human)
End	34,710,136 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	42,773,993 bp
RNA expression pattern
	Top expressed in
	lymph node; ; right lobe of thyroid gland; ; appendix; ; left lobe of thyroid gland; ; rectum; ; gallbladder; ; gastric mucosa; ; right uterine tube; ; upper lobe of left lung; ; spleen;
	Top expressed in
	thymus; ; spleen; ; urinary bladder; ; lip; ; ovary; ; lung; ; esophagus; ; uterus; ; colon; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; chemokine receptor binding; CCR7 chemokine receptor binding; chemokine activity; CCR chemokine receptor binding; protein binding;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of leukocyte tethering or rolling; release of sequestered calcium ion into cytosol; positive regulation of receptor-mediated endocytosis; positive regulation of protein kinase B signaling; positive regulation of cell motility; positive regulation of actin filament polymerization; monocyte chemotaxis; activation of GTPase activity; ruffle organization; positive regulation of cell-matrix adhesion; chemokine-mediated signaling pathway; cellular response to tumor necrosis factor; cell-cell signaling; T cell costimulation; cell maturation; positive regulation of JNK cascade; dendritic cell chemotaxis; negative regulation of dendritic cell dendrite assembly; positive regulation of phosphatidylinositol 3-kinase activity; chemotaxis; response to prostaglandin E; positive regulation of dendritic cell antigen processing and presentation; dendritic cell dendrite assembly; positive regulation of pseudopodium assembly; mesangial cell-matrix adhesion; positive regulation of chemotaxis; cellular response to interleukin-1; immune response; establishment of T cell polarity; positive regulation of ERK1 and ERK2 cascade; positive regulation of glycoprotein biosynthetic process; cellular response to interferon-gamma; positive regulation of I-kappaB kinase/NF-kappaB signaling; cell chemotaxis; lymphocyte chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation of cell adhesion mediated by integrin; immunological synapse formation; positive regulation of filopodium assembly; positive regulation of T cell migration; positive regulation of myeloid dendritic cell chemotaxis; positive regulation of protein kinase activity; inflammatory response; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; negative regulation of dendritic cell apoptotic process; positive regulation of T cell chemotaxis; neutrophil chemotaxis; chemokine (C-C motif) ligand 21 signaling pathway; positive regulation of GTPase activity; cellular response to chemokine;
	Sources:Amigo / QuickGO
Orthologs
	6366
	18829
	ENSG00000137077
	ENSMUSG00000094686
	O00585
	P84444
	NM_002989
	NM_011124
	NP_002980
	NP_035254
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7. The main function of CCL21 is to guide CCR7 expressing leukocytes to the secondary lymphoid organs, such as lymph nodes and Peyer´s patches.

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