CCL19

CCL19
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2MP1
Identifiers
Aliases	CCL19, CKb11, ELC, MIP-3b, MIP3B, SCYA19, C-C motif chemokine ligand 19
External IDs	OMIM: 602227 MGI: 5434459 HomoloGene: 4569 GeneCards: CCL19
Gene location (Human)
Chr.	Chromosome 9 (human)
End	34,691,276 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	42,072,779 bp
RNA expression pattern
	Top expressed in
	appendix; ; lymph node; ; gallbladder; ; thymus; ; rectum; ; left coronary artery; ; right coronary artery; ; thymus; ; gastric mucosa; ; right lobe of thyroid gland;
	Top expressed in
	spleen; ; adrenal gland; ; superior frontal gyrus; ; thymus; ; lip; ; zone of skin; ; kidney; ; islet of Langerhans; ; cerebellar cortex; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	CCR10 chemokine receptor binding; cytokine activity; chemokine receptor binding; CCR7 chemokine receptor binding; chemokine activity; CCR chemokine receptor binding; protein binding;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	release of sequestered calcium ion into cytosol; positive regulation of receptor-mediated endocytosis; positive regulation of protein kinase B signaling; positive regulation of cell motility; positive regulation of dendritic cell dendrite assembly; positive regulation of interleukin-12 production; regulation of cell projection assembly; monocyte chemotaxis; positive regulation of T-helper 1 cell differentiation; chemokine-mediated signaling pathway; response to nitric oxide; cellular response to tumor necrosis factor; T cell costimulation; response to virus; cellular calcium ion homeostasis; cell maturation; myeloid dendritic cell chemotaxis; positive regulation of JNK cascade; dendritic cell chemotaxis; positive regulation of phosphatidylinositol 3-kinase activity; chemotaxis; cell communication; positive regulation of endocytosis; positive regulation of GTPase activity; response to prostaglandin E; positive regulation of dendritic cell antigen processing and presentation; positive regulation of chemotaxis; cellular response to interleukin-1; positive regulation of T cell proliferation; immune response; positive regulation of ERK1 and ERK2 cascade; establishment of T cell polarity; positive regulation of glycoprotein biosynthetic process; cellular response to interferon-gamma; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB signaling; lymphocyte chemotaxis; positive regulation of neutrophil chemotaxis; inflammatory response; immunological synapse formation; mature conventional dendritic cell differentiation; positive regulation of protein kinase activity; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; negative regulation of dendritic cell apoptotic process; cytokine-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; neutrophil chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6363
	100861647
	ENSG00000172724
	ENSMUSG00000118633
	Q99731
	n/a
	NM_006274
	XM_006538413
	NP_006265
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-C motif) ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene.

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.

Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen. The gene for CCL19 is located on human chromosome 9. This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells, CCR7+ central-memory T-Cells.

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