Adenine nucleotide translocator
Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. ANT is the most abundant protein in the inner mitochondrial membrane and belongs to mitochondrial carrier family.
| ADP/ATP translocases | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Cytoplasmic view of the binding pocket of ATP–ADP translocase 1, PDB: 1OKC. | |||||||||
| Identifiers | |||||||||
| Symbol | Aden_trnslctor | ||||||||
| Pfam | PF00153 | ||||||||
| InterPro | IPR002113 | ||||||||
| TCDB | 2.A.29.1.2 | ||||||||
| OPM superfamily | 21 | ||||||||
| OPM protein | 2c3e | ||||||||
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| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SLC25A4 | ||||||
| Alt. symbols | PEO3, PEO2, ANT1 | ||||||
| NCBI gene | 291 | ||||||
| HGNC | 10990 | ||||||
| OMIM | 103220 | ||||||
| RefSeq | NM_001151 | ||||||
| UniProt | P12235 | ||||||
| Other data | |||||||
| Locus | Chr. 4 q35 | ||||||
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| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SLC25A5 | ||||||
| Alt. symbols | ANT2 | ||||||
| NCBI gene | 292 | ||||||
| HGNC | 10991 | ||||||
| OMIM | 300150 | ||||||
| RefSeq | NM_001152 | ||||||
| UniProt | P05141 | ||||||
| Other data | |||||||
| Locus | Chr. X q24-q26 | ||||||
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| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SLC25A6 | ||||||
| Alt. symbols | ANT3 | ||||||
| NCBI gene | 293 | ||||||
| HGNC | 10992 | ||||||
| OMIM | 403000 | ||||||
| RefSeq | NM_001636 | ||||||
| UniProt | P12236 | ||||||
| Other data | |||||||
| Locus | Chr. Y p | ||||||
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Free ADP is transported from the cytoplasm to the mitochondrial matrix, while ATP produced from oxidative phosphorylation is transported from the mitochondrial matrix to the cytoplasm, thus providing the cells with its main energy currency. ADP/ATP translocases are exclusive to eukaryotes and are thought to have evolved during eukaryogenesis. Human cells express four ADP/ATP translocases: SLC25A4, SLC25A5, SLC25A6 and SLC25A31, which constitute more than 10% of the protein in the inner mitochondrial membrane. These proteins are classified under the mitochondrial carrier superfamily.