ADP/ATP translocase 2

SLC25A5
Identifiers
Aliases	SLC25A5, 2F1, AAC2, ANT2, T2, T3, solute carrier family 25 member 5
External IDs	OMIM: 300150 MGI: 1353496 HomoloGene: 55557 GeneCards: SLC25A5
Gene location (Human)
Chr.	X chromosome (human)
End	119,471,396 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	36,062,460 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; jejunal mucosa; ; thymus; ; duodenum; ; vulva; ; human penis; ; pylorus; ; nipple; ; pons; ; kidney;
	Top expressed in
	hair follicle; ; epithelium of stomach; ; left colon; ; primitive streak; ; jejunum; ; atrioventricular valve; ; blastocyst; ; endocardial cushion; ; medullary collecting duct; ; kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	transporter activity; protein binding; adenine transmembrane transporter activity; ubiquitin protein ligase binding; RNA binding; ATP:ADP antiporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; myelin sheath; integral component of plasma membrane; mitochondrion; mitochondrial nucleoid; extracellular exosome; nucleus; MMXD complex; extracellular matrix; mitochondrial inner membrane; membrane raft;
Biological process	regulation of insulin secretion; chromosome segregation; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; transmembrane transport; positive regulation of cell population proliferation; viral process; adenine transport; ADP transport; ATP transport; cellular response to leukemia inhibitory factor; transport;
	Sources:Amigo / QuickGO
Orthologs
	292
	11740
	ENSG00000005022
	ENSMUSG00000016319
	P05141; Q6NVC0
	P51881
	NM_001152
	NM_007451
	NP_001143; NP_001143.2
	NP_031477
	Wikidata
View/Edit Human	View/Edit Mouse

ADP/ATP translocase 2 is a protein that in humans is encoded by the SLC25A5 gene on the X chromosome.

This protein functions as an antiporter for ADP/ATP exchange between the mitochondrial matrix and cytoplasm. As a result, it plays a key role in maintaining mitochondrial membrane potential and inhibiting apoptosis and has been targeted for treating cancer.

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