ADP/ATP translocase 4

SLC25A31
Identifiers
Aliases	SLC25A31, AAC4, ANT4, SFEC35kDa, ANT 4, solute carrier family 25 member 31
External IDs	OMIM: 610796 MGI: 1920583 HomoloGene: 69485 GeneCards: SLC25A31
Gene location (Human)
Chr.	Chromosome 4 (human)
End	127,774,292 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	40,680,527 bp
RNA expression pattern
	Top expressed in
	sperm; ; lower lobe of lung; ; pancreatic epithelial cell; ; pancreatic ductal cell; ; tibialis anterior muscle; ; amygdala; ; ovary; ; gastrocnemius muscle; ; connective tissue; ; adipose tissue;
	Top expressed in
	spermatocyte; ; spermatid; ; right lung; ; secondary oocyte; ; testicle; ; urethra; ; left lung; ; morula; ; pituitary gland; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; transmembrane transporter activity; ATP:ADP antiporter activity;
Cellular component	cell projection; motile cilium; cilium; membrane; mitochondrion; nucleus; mitochondrial inner membrane; integral component of membrane;
Biological process	transmembrane transport; mitochondrial transport; transport; ADP transport; ATP transport;
	Sources:Amigo / QuickGO
Orthologs
	83447
	73333
	ENSG00000151475
	ENSMUSG00000069041
	Q9H0C2
	Q3V132
	NM_031291; NM_001318467
	NM_178386
	NP_001305396; NP_112581
	NP_848473
	Wikidata
View/Edit Human	View/Edit Mouse

ADP/ATP translocase 4 (ANT4) is an enzyme that in humans is encoded by the SLC25A31 gene on chromosome 4. This enzyme inhibits apoptosis by catalyzing ADP/ATP exchange across the mitochondrial membranes and regulating membrane potential. In particular, ANT4 is essential to spermatogenesis, as it imports ATP into sperm mitochondria to support their development and survival. Outside this role, the SLC25AC31 gene has not been implicated in any human disease.

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