Intelectin

Intelectins are lectins (carbohydrate-binding proteins) expressed in humans and other chordates. Humans express two types of intelectins encoded by ITLN1 and ITLN2 genes respectively. Several intelectins bind microbe-specific carbohydrate residues. Therefore, intelectins have been proposed to function as immune lectins. Even though intelectins contain fibrinogen-like domain found in the ficolins family of immune lectins, there is significant structural divergence. Thus, intelectins may not function through the same lectin-complement pathway. Most intelectins are still poorly characterized and they may have diverse biological roles. Human intelectin-1 (hIntL-1) has also been shown to bind lactoferrin, but the functional consequence has yet to be elucidated. Additionally, hIntL-1 is a major component of asthmatic mucus and may be involved in insulin physiology as well.

Xenopus embryonic epidermal lectin
Monomeric structure of XEEL-CRD with bound D-glycerol 1-phosphate. The protein is colored using a blue-red gradient from the N- to the C- terminus. Calcium ions are shown as green spheres and the coordinated water molecules are shown as red spheres.
Identifiers
OrganismXenopus laevis
Symbolitln1
Entrez398574
HomoloGene111044
PDB4WN0
RefSeq (mRNA)NM_001089101.1
RefSeq (Prot)NP_001082570.1
UniProtQ800K0
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StructuresSwiss-model
DomainsInterPro
Human intelectin-1
Monomeric structure of human intelectin with bound allyl-beta-D-galactofuranose. The protein is colored using a blue-red gradient from the N- to the C- terminus. Calcium ions are shown as green spheres and the coordinated water molecules are shown as red spheres.
Identifiers
SymbolITLN1
Alt. symbolshIntL-1
NCBI gene55600
HGNC18259
OMIM609873
PDB4WMY
RefSeqNP_060095
UniProtQ8WWA0
Other data
LocusChr. 1 q21.3
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StructuresSwiss-model
DomainsInterPro
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