Intelectin-1

ITLN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WMQ, 4WMY
Identifiers
Aliases	ITLN1, HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin, intelectin 1
External IDs	OMIM: 609873 MGI: 1333831 HomoloGene: 111044 GeneCards: ITLN1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,885,180 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,362,862 bp
RNA expression pattern
	Top expressed in
	parietal pleura; ; pericardium; ; germinal epithelium; ; rectum; ; jejunal mucosa; ; duodenum; ; right coronary artery; ; vena cava; ; popliteal artery; ; appendix;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; Paneth cell; ; duodenum; ; jejunum; ; intestinal villus; ; ileum; ; cervix; ; left colon; ; gastric mucosa; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	carbohydrate binding; calcium ion binding; oligosaccharide binding; metal ion binding; identical protein binding;
Cellular component	membrane raft; anchored component of membrane; brush border membrane; receptor complex; plasma membrane; extracellular exosome; membrane; extracellular region;
Biological process	positive regulation of glucose import; positive regulation of protein phosphorylation; response to nematode; antimicrobial humoral response; protein homotrimerization;
	Sources:Amigo / QuickGO
Orthologs
	55600
	16429
	ENSG00000179914
	ENSMUSG00000038209
	Q8WWA0
	O88310
	NM_017625
	NM_010584
	NP_060095
	NP_034714
	Wikidata
View/Edit Human	View/Edit Mouse

Intelectin-1, also known as omentin or intestinal lactoferrin receptor, is an intelectin encoded in humans by the ITLN1 gene. Intelectin-1 functions both as a receptor for bacterial arabinogalactans and for lactoferrin.

Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.

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