KAT7 (gene)

KAT7
Identifiers
Aliases	KAT7, HBO1, HBOA, MYST2, ZC2HC7, lysine acetyltransferase 7
External IDs	OMIM: 609880 MGI: 2182799 HomoloGene: 5134 GeneCards: KAT7
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,835,026 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,201,072 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; testicle; ; Achilles tendon; ; popliteal artery; ; ganglionic eminence; ; cerebellar hemisphere; ; gastrocnemius muscle; ; tibialis anterior muscle; ; sperm; ; bone marrow cells;
	Top expressed in
	spermatocyte; ; ankle joint; ; spermatid; ; secondary oocyte; ; seminiferous tubule; ; cumulus cell; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA-binding transcription factor activity; zinc ion binding; metal ion binding; histone acetyltransferase activity; protein binding; acyltransferase activity; DNA replication origin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; H4 histone acetyltransferase activity; histone binding;
Cellular component	nucleoplasm; nucleolus; histone acetyltransferase complex; nucleus; cytoplasm; cytosol;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; histone H4-K5 acetylation; DNA replication; histone H3 acetylation; histone H4-K16 acetylation; histone H4-K8 acetylation; histone H4-K12 acetylation; positive regulation of protein localization to nucleus; stress-activated protein kinase signaling cascade; positive regulation of transcription by RNA polymerase II; response to sorbitol; response to hydroxyurea; response to actinomycin D; response to dithiothreitol; response to anisomycin; positive regulation of histone H4 acetylation; histone acetylation; chromatin organization; negative regulation of transcription, DNA-templated; internal peptidyl-lysine acetylation;
	Sources:Amigo / QuickGO
Orthologs
	11143
	217127
	ENSG00000136504
	ENSMUSG00000038909
	O95251
	Q5SVQ0
NM_001199155; NM_001199156; NM_001199157; NM_001199158; NM_007067;
	NM_001346706
	NM_001195003; NM_001195004; NM_177619
NP_001186084; NP_001186085; NP_001186086; NP_001186087; NP_001333635;
	NP_008998
NP_001181932; NP_001181933; NP_808287; NP_001392123; NP_001392124;
	NP_001392125; NP_001392126; NP_001392127; NP_001392128; NP_001392129; NP_001392130; NP_001392131; NP_001392132; NP_001392133; NP_001392134; NP_001392135; NP_001392136; NP_001392137; NP_001392138; NP_001392139; NP_001392140; NP_001392141; NP_001392142; NP_001392143; NP_001392144; NP_001392145; NP_001392146; NP_001392147; NP_001392148; NP_001392149; NP_001392150; NP_001392151; NP_001392152; NP_001392153; NP_001392154; NP_001392155; NP_001392156
	Wikidata
View/Edit Human	View/Edit Mouse

Histone acetyltransferase KAT7 is an enzyme that in humans is encoded by the KAT7 gene. It specifically acetylates H4 histones at the lysine12 residue (H4K12) and is necessary for origin licensing and DNA replication. KAT7 associates with origins of replication during G1 phase of the cell cycle through complexing with CDT1. Geminin is thought to inhibit the acetyltransferase activity of KAT7 when KAT7 and CDT1 are complexed together.

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