Geminin

GMNN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T6F, 1UII, 2LP0, 2WVR, 4BRY
Identifiers
Aliases	GMNN, Gem, MGORS6, geminin, DNA replication inhibitor, geminin DNA replication inhibitor
External IDs	OMIM: 602842 MGI: 1927344 HomoloGene: 9292 GeneCards: GMNN
Gene location (Human)
Chr.	Chromosome 6 (human)
End	24,786,099 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	24,945,906 bp
RNA expression pattern
	Top expressed in
	oocyte; ; body of pancreas; ; secondary oocyte; ; embryo; ; rectum; ; ganglionic eminence; ; palpebral conjunctiva; ; skin of abdomen; ; endometrium; ; spongy bone;
	Top expressed in
	primitive streak; ; morula; ; yolk sac; ; Paneth cell; ; medial ganglionic eminence; ; abdominal wall; ; endocardial cushion; ; spermatocyte; ; hair follicle; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone deacetylase binding; protein binding; transcription corepressor activity; chromatin binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol;
Biological process	animal organ morphogenesis; cell cycle; negative regulation of cell cycle; negative regulation of DNA replication; negative regulation of transcription, DNA-templated; regulation of DNA replication; positive regulation of chromatin binding; DNA replication preinitiation complex assembly; negative regulation of DNA-dependent DNA replication; protein-containing complex assembly; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	51053
	57441
	ENSG00000112312
	ENSMUSG00000006715
	O75496
	O88513
	NM_001251989; NM_001251990; NM_001251991; NM_015895
	NM_020567
	NP_001238918; NP_001238919; NP_001238920; NP_056979
	NP_065592
	Wikidata
View/Edit Human	View/Edit Mouse

Geminin, DNA replication inhibitor, also known as GMNN, is a protein in humans encoded by the GMNN gene. A nuclear protein present in most eukaryotes and highly conserved across species, numerous functions have been elucidated for geminin including roles in metazoan cell cycle, cellular proliferation, cell lineage commitment, and neural differentiation. One example of its function is the inhibition of Cdt1.

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