Janus kinase 2

JAK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5AEP, 2B7A, 2W1I, 2XA4, 3E62, 3E63, 3E64, 3FUP, 3IO7, 3IOK, 3JY9, 3KCK, 3KRR, 3LPB, 3Q32, 3RVG, 3TJC, 3TJD, 3UGC, 3ZMM, 4AQC, 4BBE, 4BBF, 4C61, 4C62, 4D0W, 4D0X, 4D1S, 4E4M, 4E6D, 4E6Q, 4F08, 4F09, 4FVP, 4FVQ, 4FVR, 4GFM, 4GMY, 4HGE, 4IVA, 4JI9, 4JIA, 4P7E, 4ZIM, 4YTC, 4YTF, 4YTH, 4YTI, 5CF4, 5CF5, 5CF6, 5CF8, 5I4N, 4Z32, 5L3A
Identifiers
Aliases	JAK2, JTK10, THCYT3, Janus kinase 2, MAX2
External IDs	OMIM: 147796 MGI: 96629 HomoloGene: 21033 GeneCards: JAK2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	5,129,948 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	29,290,480 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; monocyte; ; popliteal artery; ; ascending aorta; ; sural nerve; ; tibia; ; left coronary artery; ; right coronary artery; ; bone marrow cells; ; superficial temporal artery;
	Top expressed in
	secondary oocyte; ; blood; ; Paneth cell; ; jejunum; ; uterus; ; fossa; ; cumulus cell; ; substantia nigra; ; knee joint; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH2 domain binding; kinase activity; signaling receptor binding; ATP binding; growth hormone receptor binding; interleukin-12 receptor binding; metal ion binding; heme binding; histone kinase activity (H3-Y41 specific); transferase activity; histone binding; protein binding; protein tyrosine kinase activity; protein kinase binding; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; identical protein binding; protein kinase activity; protein C-terminus binding; type 1 angiotensin receptor binding; acetylcholine receptor binding; phosphatidylinositol 3-kinase binding; insulin receptor substrate binding; peptide hormone receptor binding;
Cellular component	cytoplasm; cytosol; membrane; extrinsic component of cytoplasmic side of plasma membrane; caveola; cytoskeleton; nucleus; nuclear matrix; endosome lumen; membrane raft; endomembrane system; nucleoplasm; plasma membrane; focal adhesion; postsynapse; glutamatergic synapse;
Biological process	negative regulation of neuron apoptotic process; intrinsic apoptotic signaling pathway in response to oxidative stress; adaptive immune response; interferon-gamma-mediated signaling pathway; negative regulation of DNA binding; tumor necrosis factor-mediated signaling pathway; protein phosphorylation; positive regulation of phosphoprotein phosphatase activity; growth hormone receptor signaling pathway; positive regulation of interleukin-1 beta production; positive regulation of DNA binding; mesoderm development; activation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of cell population proliferation; apoptotic process; regulation of apoptotic process; positive regulation of cell activation; mammary gland epithelium development; extrinsic apoptotic signaling pathway; axon regeneration; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; response to antibiotic; positive regulation of nitric-oxide synthase biosynthetic process; response to oxidative stress; response to tumor necrosis factor; response to interleukin-12; positive regulation of cell differentiation; positive regulation of tumor necrosis factor production; positive regulation of peptidyl-tyrosine phosphorylation; erythrocyte differentiation; protein autophosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of cell-substrate adhesion; positive regulation of growth hormone receptor signaling pathway; G protein-coupled receptor signaling pathway; cell differentiation; growth hormone receptor signaling pathway via JAK-STAT; positive regulation of inflammatory response; phosphorylation; immune system process; positive regulation of DNA-binding transcription factor activity; negative regulation of cardiac muscle cell apoptotic process; actin filament polymerization; response to lipopolysaccharide; regulation of inflammatory response; peptidyl-tyrosine autophosphorylation; enzyme linked receptor protein signaling pathway; positive regulation of insulin secretion; receptor signaling pathway via JAK-STAT; intracellular signal transduction; negative regulation of cell-cell adhesion; mineralocorticoid receptor signaling pathway; negative regulation of heart contraction; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration; positive regulation of nitric oxide biosynthetic process; blood coagulation; response to hydroperoxide; MAPK cascade; regulation of interferon-gamma-mediated signaling pathway; regulation of cell population proliferation; positive regulation of cell population proliferation; hormone-mediated signaling pathway; positive regulation of apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; cell migration; signal transduction; positive regulation of epithelial cell apoptotic process; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; innate immune response; negative regulation of cell death; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; activation of Janus kinase activity; tyrosine phosphorylation of STAT protein; interleukin-12-mediated signaling pathway; cytokine-mediated signaling pathway; interleukin-23-mediated signaling pathway; interleukin-6-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; chromatin organization; regulation of receptor signaling pathway via JAK-STAT; regulation of nitric oxide biosynthetic process; positive regulation of Ras protein signal transduction; modulation of chemical synaptic transmission; postsynapse to nucleus signaling pathway; positive regulation of cold-induced thermogenesis; microglial cell activation; positive regulation of MHC class II biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	3717
	16452
	ENSG00000096968
	ENSMUSG00000024789
	O60674
	Q62120
NM_004972; NM_001322194; NM_001322195; NM_001322196; NM_001322198;
	NM_001322199; NM_001322204
	NM_001048177; NM_008413
NP_001309123; NP_001309124; NP_001309125; NP_001309127; NP_001309128;
	NP_001309133; NP_004963
	NP_001041642; NP_032439
	Wikidata
View/Edit Human	View/Edit Mouse

Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R).

The distinguishing feature between janus kinase 2 and other JAK kinases is the lack of Src homology binding domains (SH2/SH3) and the presence of up to seven JAK homology domains (JH1-JH7). Nonetheless the terminal JH domains retain a high level of homology to tyrosine kinase domains. An interesting note is that only one of these carboxy-terminal JH domains retains full kinase function (JH1) while the other (JH2), previously thought to have no kinase functionality and accordingly termed a pseudokinase domain, has since been found to be catalytically active, albeit at only 10% that of the JH1 domain.

Loss of Jak2 is lethal by embryonic day 12 in mice.

JAK2 orthologs have been identified in all mammals for which complete genome data are available.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.