Interleukin 12 receptor, beta 2 subunit

IL12RB2
Identifiers
Aliases	IL12RB2, Interleukin 12 receptor, beta 2 subunit, interleukin 12 receptor subunit beta 2
External IDs	OMIM: 601642 MGI: 1270861 HomoloGene: 1197 GeneCards: IL12RB2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	67,398,724 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	67,353,172 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; body of pancreas; ; Achilles tendon; ; prefrontal cortex; ; lymph node; ; cingulate gyrus; ; right lobe of liver; ; appendix; ; Brodmann area 9; ; placenta;
	Top expressed in
	secondary oocyte; ; thymus; ; morula; ; blastocyst; ; striated muscle tissue; ; skeletal muscle tissue; ; zone of skin; ; superior frontal gyrus; ; neck; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; protein kinase binding; cytokine binding;
Cellular component	integral component of membrane; external side of plasma membrane; integral component of plasma membrane; plasma membrane; membrane; receptor complex;
Biological process	response to lipopolysaccharide; cell surface receptor signaling pathway; positive regulation of cell population proliferation; positive regulation of interferon-gamma production; peptidyl-tyrosine phosphorylation; response to cytokine; interleukin-12-mediated signaling pathway; interleukin-35-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3595
	16162
	ENSG00000081985
	ENSMUSG00000018341
	Q99665
	P97378
NM_001258214; NM_001258215; NM_001258216; NM_001559; NM_001319233;
	NM_001374259
	NM_008354; NM_001311141
NP_001245143; NP_001245144; NP_001245145; NP_001306162; NP_001550;
	NP_001361188
	NP_001298070; NP_032380
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 orthologs have been identified in all mammals for which complete genome data are available.

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and IL12Rβ1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12Rβ1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL12Rβ2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.

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