Interleukin-27 receptor
The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit and glycoprotein 130.
| interleukin 27 receptor, alpha | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL27RA | ||||||
| Alt. symbols | WSX-1, TCCR, CRL1, WSX1, zcytor1, IL-27R | ||||||
| NCBI gene | 9466 | ||||||
| HGNC | 17290 | ||||||
| OMIM | 605350 | ||||||
| RefSeq | NM_004843 | ||||||
| UniProt | Q6UWB1 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.11 | ||||||
| |||||||
| interleukin 6 signal transducer (gp130, oncostatin M receptor) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL6ST | ||||||
| Alt. symbols | GP130, CD130 | ||||||
| NCBI gene | 3572 | ||||||
| HGNC | 6021 | ||||||
| OMIM | 600694 | ||||||
| RefSeq | NM_002184 | ||||||
| UniProt | P40189 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q11 | ||||||
| |||||||
IL27RA essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.
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