Integrin alpha-1

ITGA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PT6, 1QC5, 1QCY, 2L8S, 4A0Q, 2M32
Identifiers
Aliases	ITGA1, CD49a, VLA1, integrin subunit alpha 1
External IDs	OMIM: 192968 MGI: 96599 HomoloGene: 57137 GeneCards: ITGA1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	52,959,209 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	115,238,500 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gastric mucosa; ; right coronary artery; ; stromal cell of endometrium; ; saphenous vein; ; right lung; ; popliteal artery; ; left coronary artery; ; ascending aorta; ; spleen;
	Top expressed in
	right lung; ; right lung lobe; ; belly cord; ; aorta; ; left lung lobe; ; ascending aorta; ; sciatic nerve; ; brown adipose tissue; ; vas deferens; ; left ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	collagen binding; metal ion binding; protein binding; collagen binding involved in cell-matrix adhesion; protein phosphatase binding; signaling receptor binding;
Cellular component	integral component of membrane; perikaryon; integrin alpha1-beta1 complex; membrane; focal adhesion; basal part of cell; plasma membrane; cell surface; integrin complex; acrosomal vesicle; membrane raft; neuron projection; extracellular exosome; external side of plasma membrane;
Biological process	neuron projection morphogenesis; muscle contraction; negative regulation of epidermal growth factor receptor signaling pathway; extracellular matrix organization; vasodilation; neutrophil chemotaxis; positive regulation of neuron apoptotic process; positive regulation of phosphoprotein phosphatase activity; cell adhesion; cell chemotaxis; integrin-mediated signaling pathway; cellular extravasation; cell-matrix adhesion; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3672
	109700
	ENSG00000213949
	ENSMUSG00000042284
	P56199
	Q3V3R4
	NM_181501
	NM_001033228
	NP_852478
	NP_001028400
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.

CD49a has been implicated as a marker of tissue resident memory T cells, where it may be coexpressed with other markers CD103 and CD69. It has been shown to affect the motility of T cells.

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