IZUMO1

IZUMO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5JKD, 5F4T, 5JKC, 5JK9, 5JKE, 5F4V, 5F4E
Identifiers
Aliases	IZUMO1, IZUMO, OBF, izumo sperm-egg fusion 1
External IDs	OMIM: 609278 MGI: 1920706 HomoloGene: 77701 GeneCards: IZUMO1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,746,909 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,628,823 bp
RNA expression pattern
	Top expressed in
	sperm; ; body of pancreas; ; upper lobe of left lung; ; body of stomach; ; right lung; ; spleen; ; left uterine tube; ; left ventricle; ; fundus; ; Brodmann area 9;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; yolk sac; ; lip; ; esophagus; ; pancreas; ; islet of Langerhans; ; placenta; ; skeletal muscle tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding; protein homodimerization activity; protein binding; identical protein binding; protein binding involved in heterotypic cell-cell adhesion;
Cellular component	membrane; integral component of membrane; plasma membrane; acrosomal membrane; cytoplasmic vesicle;
Biological process	cell adhesion; sperm-egg recognition; single fertilization; fusion of sperm to egg plasma membrane involved in single fertilization; heterotypic cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	284359
	73456
	ENSG00000182264
	ENSMUSG00000064158
	Q8IYV9
	Q9D9J7
	NM_182575; NM_001321864; NM_001321865
	NM_001018013
	NP_001308793; NP_001308794; NP_872381
	NP_001018013
	Wikidata
View/Edit Human	View/Edit Mouse

Izumo sperm-egg fusion protein 1 (Sperm-specific protein izumo) is encoded in humans by the IZUMO1 gene. In mammalian fertilisation, IZUMO1 binds to its egg receptor counterpart, Juno, to facilitate recognition and fusion of the gametes.

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