Insulin receptor substrate 1

IRS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IRS, 1K3A, 1QQG, 2Z8C
Identifiers
Aliases	IRS1, HIRS-1, insulin receptor substrate 1
External IDs	OMIM: 147545 MGI: 99454 HomoloGene: 4049 GeneCards: IRS1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	226,799,820 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	82,269,137 bp
RNA expression pattern
	Top expressed in
	tibia; ; lactiferous duct; ; vastus lateralis muscle; ; biceps brachii; ; stromal cell of endometrium; ; mucosa of urinary bladder; ; parietal pleura; ; Brodmann area 23; ; germinal epithelium; ; periodontal fiber;
	Top expressed in
	calvaria; ; pineal gland; ; triceps brachii muscle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; body of femur; ; digastric muscle; ; ankle; ; intercostal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor receptor binding; transmembrane receptor protein tyrosine kinase adaptor activity; SH2 domain binding; signal transducer activity; phosphatidylinositol 3-kinase binding; protein binding; protein kinase C binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphotyrosine residue binding; insulin receptor binding;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; caveola; insulin receptor complex; nucleus; cytosol; plasma membrane;
Biological process	positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; insulin-like growth factor receptor signaling pathway; negative regulation of insulin secretion; positive regulation of glycogen biosynthetic process; glucose homeostasis; response to peptide hormone; positive regulation of glucose metabolic process; MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; response to insulin; negative regulation of insulin receptor signaling pathway; positive regulation of cell population proliferation; cellular response to insulin stimulus; phosphatidylinositol 3-kinase signaling; positive regulation of insulin receptor signaling pathway; phosphatidylinositol-mediated signaling; signal transduction; insulin receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; interleukin-7-mediated signaling pathway; positive regulation of protein kinase B signaling; cellular response to fatty acid;
	Sources:Amigo / QuickGO
Orthologs
	3667
	16367
	ENSG00000169047
	ENSMUSG00000055980
	P35568
	P35569
	NM_005544
	NM_010570
	NP_005535
	NP_034700
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that in humans is encoded by the IRS1 gene. It is a 131 kDa protein with amino acid sequence of 1242 residues. It contains a single pleckstrin homology (PH) domain at the N-terminus and a PTB domain ca. 40 residues downstream of this, followed by a poorly conserved C-terminus tail. Together with IRS2, IRS3 (pseudogene) and IRS4, it is homologous to the Drosophila protein chico, whose disruption extends the median lifespan of flies up to 48%. Similarly, Irs1 mutant mice experience moderate life extension and delayed age-related pathologies.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.