IRS4

IRS4
Identifiers
Aliases	IRS4, IRS-4, PY160, insulin receptor substrate 4, CHNG9
External IDs	OMIM: 300904 HomoloGene: 136777 GeneCards: IRS4
Gene location (Human)
Chr.	X chromosome (human)
End	108,736,563 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; ovary; ; gastric mucosa; ; hypothalamus; ; right lobe of thyroid gland; ; cervix; ; left lobe of thyroid gland; ; canal of the cervix; ; prefrontal cortex;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol 3-kinase binding; protein binding; signal transducer activity; insulin receptor binding;
Cellular component	cytosol; membrane; plasma membrane;
Biological process	insulin receptor signaling pathway; regulation of lipid metabolic process; signal transduction; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	8471
	n/a
	ENSG00000133124
	n/a
	O14654
	n/a
	NM_003604; NM_001379150
	n/a
	NP_003595; NP_001366079
	n/a
	Wikidata
View/Edit Human

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.

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