Hydrocodone/ibuprofen

Hydrocodone/ibuprofen
Combination of
Hydrocodone	Opioid analgesic
Ibuprofen	Non-steroidal anti-inflammatory drug
Clinical data
Trade names	Ibudone, Reprexain, Vicoprofen
AHFS/Drugs.com	Professional Drug Facts
MedlinePlus	a601006
License data	US DailyMed: Hydrocodone and ibuprofen;
Dependence; liability	Moderate
Routes of; administration	By mouth
ATC code	N02AJ23 (WHO) ;
Legal status
Legal status	US: Schedule II; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	>80%
Metabolism	for hydrocodone: liver, CYP3A4; for ibuprofen: liver, CYP2C9
Elimination half-life	for hydrocodone: 228-294 mins (3.8-4.9 hrs); for ibuprofen: 108-120 mins (1.8-2 hrs)
Excretion	for hydrocodone: urinary; for ibuprofen: urine primarily (<1% unchanged)
Identifiers
KEGG	D02152 ;
CompTox Dashboard (EPA)	DTXSID80210564 ;
	(verify)

Hydrocodone/ibuprofen (INNs), sold under the brand name Vicoprofen, is a fixed-dose combination analgesic medication used in short-term therapy to relieve severe pain. Vicoprofen combines the analgesic and antitussive properties of hydrocodone with the analgesic, anti-inflammatory, and antipyretic properties of ibuprofen. In contrast to hydrocodone/acetaminophen combination analgesics such as Vicodin, this hydrocodone/ibuprofen avoids some of the liver toxicity which may occur from acetaminophen, but still presents significant dangers in hydrocodone overdose, namely respiratory depression. Vicoprofen is supplied in a fixed dose combination tablet which contains hydrocodone bitartrate, USP 7.5 mg with ibuprofen, USP 200 mg. Additional strengths of generic Vicoprofen are now available, in combinations of 5 mg/200 mg and 10 mg/200 mg respectively.

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