Histone deacetylase
Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. HDACs allow histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. HDAC's action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins. In general, they suppress gene expression.
| Histone deacetylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Catalytic domain of human histone deacetylase 4 with bound inhibitor. PDB rendering based on 2vqj. | |||||||||
| Identifiers | |||||||||
| EC no. | 3.5.1.98 | ||||||||
| CAS no. | 9076-57-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Histone deacetylase superfamily | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Hist_deacetyl | ||||||||
| Pfam | PF00850 | ||||||||
| InterPro | IPR000286 | ||||||||
| SCOP2 | 1c3s / SCOPe / SUPFAM | ||||||||
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