Histamine dihydrochloride

Histamine dihydrochloride
Clinical data
Trade names	Ceplene
License data	EU EMA: by INN;
Routes of; administration	Subcutaneous injection, topical
ATC code	L03AX14 (WHO) ;
Legal status
Legal status	Approved for use in the EU (2008) and Israel (2011);
Identifiers
	IUPAC name 2-(1H-imidazol-5-yl)ethanamine dihydrochloride;
CAS Number	56-92-8;
PubChem CID	11309913;
ChemSpider	5613;
UNII	3POA0Q644U;
CompTox Dashboard (EPA)	DTXSID1058767 ;
ECHA InfoCard	100.000.272
Chemical and physical data
Formula	C5H11Cl2N3
Molar mass	184.06 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=C(NC=N1)CCN.Cl.Cl;
	InChI InChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H; Key:PPZMYIBUHIPZOS-UHFFFAOYSA-N;

Histamine dihydrochloride (INN, trade name Ceplene) is a salt of histamine that is used as a drug for the prevention of relapse in patients diagnosed with acute myeloid leukemia (AML).

It is also an FDA-approved active ingredient for topical analgesic use for the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains, and strains and is available in over-the-counter (OTC) products such as Australian Dream and Golden Creme.

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