HK3

HK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HM8
Identifiers
Aliases	HK3, HKIII, HXK3, hexokinase 3
External IDs	OMIM: 142570 MGI: 2670962 HomoloGene: 55633 GeneCards: HK3
Gene location (Human)
Chr.	Chromosome 5 (human)
End	176,899,346 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,169,198 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spleen; ; bone marrow cells; ; blood; ; upper lobe of left lung; ; spongy bone; ; right lung; ; appendix; ; left uterine tube; ; amniotic fluid;
	Top expressed in
	bone marrow; ; calvaria; ; blood; ; spleen; ; liver; ; jejunum; ; body of femur; ; thyroid gland; ; tongue; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; mannokinase activity; hexokinase activity; phosphotransferase activity, alcohol group as acceptor; glucose binding; kinase activity; catalytic activity; fructokinase activity; ATP binding; glucokinase activity;
Cellular component	cytosol; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen;
Biological process	glycolytic process; phosphorylation; canonical glycolysis; cellular glucose homeostasis; carbohydrate phosphorylation; hexose metabolic process; metabolism; glucose 6-phosphate metabolic process; neutrophil degranulation; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3101
	212032
	ENSG00000160883
	ENSMUSG00000025877
	P52790
	Q3TRM8
	NM_002115
	NM_001033245; NM_001206390; NM_001206391; NM_001206392
	NP_002106
	NP_001028417; NP_001193319; NP_001193320; NP_001193321
	Wikidata
View/Edit Human	View/Edit Mouse

Hexokinase 3 also known as HK3 is an enzyme which in humans is encoded by the HK3 gene on chromosome 5. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

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