Glycine receptor, alpha 1

GLRA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MOT, 1VRY, 2M6B, 2M6I, 4X5T
Identifiers
Aliases	GLRA1, HKPX1, STHE, Glycine receptor, alpha 1, glycine receptor alpha 1
External IDs	OMIM: 138491 MGI: 95747 HomoloGene: 20083 GeneCards: GLRA1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	151,924,851 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	55,499,024 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; hypothalamus; ; substantia nigra; ; ganglionic eminence; ; cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; putamen; ; body of pancreas; ; prefrontal cortex;
	Top expressed in
	medial vestibular nucleus; ; ventromedial nucleus; ; pontine nuclei; ; anterior horn of spinal cord; ; dorsal tegmental nucleus; ; facial motor nucleus; ; superior colliculus; ; lateral hypothalamus; ; medial dorsal nucleus; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; glycine binding; metal ion binding; transmitter-gated ion channel activity; extracellularly glycine-gated chloride channel activity; protein binding; extracellularly glycine-gated ion channel activity; taurine binding; chloride channel activity; extracellular ligand-gated ion channel activity; ion channel activity; identical protein binding; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; perikaryon; postsynaptic membrane; cell projection; intracellular membrane-bounded organelle; membrane; plasma membrane; synapse; integral component of plasma membrane; inhibitory synapse; intracellular anatomical structure; chloride channel complex; cell junction; dendrite; endoplasmic reticulum; external side of plasma membrane; neuronal cell body; neuron projection; calyx of Held; glycinergic synapse; integral component of presynaptic membrane; integral component of postsynaptic specialization membrane;
Biological process	inhibitory postsynaptic potential; muscle contraction; startle response; neuromuscular process controlling posture; cellular response to ethanol; protein heterooligomerization; regulation of respiratory gaseous exchange; regulation of membrane potential; ion transport; anion transport; cellular response to zinc ion; regulation of respiratory gaseous exchange by nervous system process; acrosome reaction; positive regulation of acrosome reaction; neuromuscular process; cellular response to amino acid stimulus; synaptic transmission, glycinergic; action potential; chloride transport; righting reflex; neuropeptide signaling pathway; protein homooligomerization; negative regulation of transmission of nerve impulse; visual perception; adult walking behavior; chloride transmembrane transport; response to alcohol; excitatory postsynaptic potential; chemical synaptic transmission; ion transmembrane transport; signal transduction; response to amino acid; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	2741
	14654
	ENSG00000145888
	ENSMUSG00000000263
	P23415
	Q64018
	NM_000171; NM_001146040; NM_001292000
	NM_001290821; NM_020492
	NP_000162; NP_001139512; NP_001278929
	NP_001277750; NP_065238
	Wikidata
View/Edit Human	View/Edit Mouse

Glycine receptor subunit alpha-1 is a protein that in humans is encoded by the GLRA1 gene.

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