Gastrin-releasing peptide

GRP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N0B, 2N0C, 2N0D, 2N0E, 2N0F, 2N0G, 2N0H
Identifiers
Aliases	GRP, BN, GRP-10, preproprogastrin releasing peptide
External IDs	OMIM: 137260 MGI: 95833 HomoloGene: 1580 GeneCards: GRP
Gene location (Human)
Chr.	Chromosome 18 (human)
End	59,230,774 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	66,019,667 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; gastric mucosa; ; sperm; ; lactiferous duct; ; cingulate gyrus; ; tibia; ; hippocampus proper; ; prefrontal cortex; ; amygdala; ; bronchial epithelial cell;
	Top expressed in
	subiculum; ; suprachiasmatic nucleus; ; barrel cortex; ; ventral tegmental area; ; hippocampus proper; ; external carotid artery; ; dorsomedial hypothalamic nucleus; ; internal carotid artery; ; amygdala; ; Region I of hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; neuropeptide hormone activity;
Cellular component	extracellular region; extracellular space; secretory granule lumen; cytoplasmic vesicle;
Biological process	neuropeptide signaling pathway; signal transduction; social behavior; psychomotor behavior; response to external biotic stimulus; positive regulation of peptide hormone secretion; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2922
	225642
	ENSG00000134443
	ENSMUSG00000024517
	P07492
	Q8R1I2
	NM_001012512; NM_001012513; NM_002091
	NM_175012
	NP_002082; NP_001012531; NP_001012530
	NP_778177
	Wikidata
View/Edit Human	View/Edit Mouse

Gastrin-releasing peptide GRP, is a neuropeptide, a regulatory molecule encoded in the human by the GRP gene. GRP has been implicated in a number of physiological and pathophysiological processes. Most notably, GRP stimulates the release of gastrin from the G cells of the stomach.

GRP encodes a number of bombesin-like peptides. Its 148-amino acid preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27-amino acid gastrin-releasing peptide or the 10-amino acid neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.

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