Gastrin

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Gastrin
Gastrin
Identifiers
Symbol	Gastrin
Pfam	PF00918
InterPro	IPR001651
PROSITE	PDOC00232
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

GAST
Identifiers
Aliases	GAST, GAS, gastrin
External IDs	OMIM: 137250 MGI: 104768 HomoloGene: 628 GeneCards: GAST
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,715,969 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,227,822 bp
RNA expression pattern
	Top expressed in
	pylorus; ; duodenum; ; pancreatic ductal cell; ; islet of Langerhans; ; placenta; ; metanephros; ; hypothalamus; ; upper respiratory tract; ; endometrium; ; hippocampal formation;
	Top expressed in
	pyloric antrum; ; epithelium of stomach; ; mucous cell of stomach; ; morula; ; cingulate gyrus; ; entorhinal cortex; ; duodenum; ; dentate gyrus; ; lens; ; primary motor cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; hormone activity;
Cellular component	extracellular region; extracellular space;
Biological process	response to food; signal transduction; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2520
	14459
	ENSG00000184502
	ENSMUSG00000017165
	P01350
	P48757
	NM_000805
	NM_010257
	NP_000796
	NP_034387
	Wikidata
View/Edit Human	View/Edit Mouse

Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.

Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it induces the insertion of K⁺/H⁺ ATPase pumps into the apical membrane of parietal cells (which in turn increases H⁺ release into the stomach cavity). Its release is stimulated by peptides in the lumen of the stomach.

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